Valasani Koteswara Rao

TL;DR: The CypD-dependent mPTP is directly linked to the cellular and synaptic perturbations observed in the pathogenesis of AD and designed small molecules to block this interaction would lessen the effects of Aβ neurotoxicity.

TL;DR: The main objective of the present work is to carry out the QSAR studies for all the series of the compounds starting from 4a to 6j to find out their molecular descriptors and predict the biological properties, and to consider these molecules as potential antiviral drugs.

TL;DR: The novel phosphorylated derivatives of Lamivudine (5a-5l) as potential anti colon cancer agents are synthe- sized and among them 5a and 5b emerged as lead compounds with 0.003 μM and 0.0001 μM values.

TL;DR: The lactate dehydrogenase (LDH) gene which catalyzes the formation of lactate was cloned, sequenced, and expressed in Escherichia coli DH5α and the LDH gene sequence "LKDIMA" was found to be conserved in all Gram positive bacteria and in all human LDH isoforms even though only 39% sequence homology was observed with all human LH isoforms.

TL;DR: The analysis revealed that the four ATP binding domains are showing 13 identical, 7 similar and 6 dissimilar residues with similar structural conformation, which probably explains the variable phosphorylation rates among hexokinases family.