Valeria Ciciarelli

TL;DR: It is clear that a more complex genetic network of cancer-associated genes than previously hypothesized is involved in BCC carcinogenesis, with a potential impact on the development of new molecular targeted therapies.

TL;DR: The finding of a greater incidence of irAEs among female patients ranks among the "hot topics" in gender-related differences in immuno-oncology.

TL;DR: All patients and relatives from melanoma kindreds, irrespective of their mutation status, should be encouraged to adhere to a correct ultraviolet exposure, skin self-examination, and surveillance by physicians.

TL;DR: The attention on telomere biology and telomerase activity in cSCC is increasing for the potential implications in the development of effective tools for prognostic assessment and of therapeutic strategies in patients with cutaneous cS CC.

TL;DR: Intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between primary melanomas and 39 related metastases is evaluated using molecular analysis and immunohistochemistry to demonstrate a relevant intra- patient heterogeneity between primary and metastatic lesions that is independent of clinical variables and methodological approach.