Valeria Consoli

TL;DR: In this paper, the authors present a review of HO-1-involved pathways that could be useful to promote development of new therapeutical strategies, and lay the foundation for further investigation to fully understand this important antioxidant system.

TL;DR: The results of this study show a reduction of HMG-CoA activity and of lipid droplet accumulation in the presence of the BE, suggesting the potential of BE as an anti-adipogenic agent to lower the content of cholesterol and body fat and prevent a gain in body weight.

TL;DR: The data obtained showed HO’s contribution to the onset of ferroptosis; in particular, HO-1 induction seemed to accelerate the process, and results suggest a potential role of HO-2 in erastin-induced ferroPTosis, suggesting a novel approach for breast cancer treatment.

TL;DR: A broad framework for understanding the different molecular mechanisms of DR in lung cancer is provided, and novel nanomedicine therapeutics aimed at improving the efficacy of treatment of various forms of resistant LC are presented.

TL;DR: In this article, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability.