V
Valérie Ledent
Researcher at Université libre de Bruxelles
Publications - 16
Citations - 1235
Valérie Ledent is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Hox gene & Gene. The author has an hindex of 13, co-authored 16 publications receiving 1161 citations.
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Journal ArticleDOI
The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis.
Valérie Ledent,Michel Vervoort +1 more
TL;DR: An extensive search for bHLH sequences in the completely sequenced genomes of Caenorhabditis elegans and Drosophila melanogaster found 35 and 56 different genes, respectively, which may represent the complete set of b HLH of these organisms.
Journal ArticleDOI
Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics.
Elena Simionato,Valérie Ledent,Gemma G. Richards,Morgane Thomas-Chollier,Morgane Thomas-Chollier,Pierre Kerner,David Coornaert,Bernard M. Degnan,Michel Vervoort +8 more
TL;DR: The first evolutionary analysis of a whole superfamily of transcription factors, the basic helix-loop-helix (bHLH) proteins, at the scale of the whole metazoan kingdom is reported, suggesting that these features may be extended to other developmental gene families and reflect a general trend in the evolution of the developmental gene repertoires of metazoans.
Journal ArticleDOI
Phylogenetic analysis of the human basic helix-loop-helix proteins
TL;DR: It is suggested that the diversification of bHLH genes is directly linked to the acquisition of multicellularity, and that important diversified of the b HLH repertoire occurred independently in animals and plants.
Journal ArticleDOI
Postembryonic development of the posterior lateral line in zebrafish.
TL;DR: This article examined how the posterior lateral line of the zebrafish grows and evolves from the simple midbody line present at the end of embryogenesis into the complex adult pattern, and showed that differentiated neuromasts migrate ventrally, and eventually generate "stitches" by successive bisections.
Journal ArticleDOI
atonal- and achaete-scute-related genes in the annelid Platynereis dumerilii: insights into the evolution of neural basic-Helix-Loop-Helix genes.
Elena Simionato,Pierre Kerner,Nicolas Dray,Martine Le Gouar,Valérie Ledent,Detlev Arendt,Michel Vervoort,Michel Vervoort +7 more
TL;DR: In this paper, the authors performed a detailed study of bHLH genes during nervous system development in the polychaete annelid, Platynereis dumerilii, an organism which is evolutionary distant from both Drosophila and vertebrates.