Valérie Petegnief

TL;DR: It is postulated that apoE promotes both the deposition and fibrillization of Abeta, ultimately affecting clearance of protease-resistant Abeta/apoE aggregates.

TL;DR: The finding that MMP-3 cleaves brain agrin strongly suggests that ischemia-induced M MP- 3 activation causes agrin cleavage.

TL;DR: In this paper, the authors investigated the effect of arsenite pre-treatment on heat shock proteins (HSPs) and showed that it increased protein kinase B (Akt) and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation after H2O2.

TL;DR: Novel pathways of SIRT1 neuroprotection are uncovered through enhancement of cell proteostatic mechanisms and activation of neurotrophic factors not previously reported such as GDNF, present in both AD-like and healthy neurons, which may increase neuron function and resilience against AD.

TL;DR: It is demonstrated that glial apoE and apoJ expression are independently regulated by LPS in microglia and astroglia, respectively, and that activatedmicroglia are the predominant source of apo E in mixed glial cultures.