Y
Yansheng Du
Researcher at Indiana University
Publications - 74
Citations - 4249
Yansheng Du is an academic researcher from Indiana University. The author has contributed to research in topics: Neuroprotection & Neurotoxicity. The author has an hindex of 30, co-authored 74 publications receiving 4045 citations. Previous affiliations of Yansheng Du include Indiana University – Purdue University Indianapolis & University of Marburg.
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Journal ArticleDOI
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
Kelly R. Bales,Tatyana Verina,Richard C. Dodel,Richard C. Dodel,Yansheng Du,Larry Altstiel,Mark H. Bender,Paul A. Hyslop,Edward M. Johnstone,Sheila P. Little,David J. Cummins,Pedro Piccardo,Bernardino Ghetti,Steven M. Paul +13 more
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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Kelly R. Bales,Tatyana Verina,David J. Cummins,Yansheng Du,Richard C. Dodel,Richard C. Dodel,Josep Saura,Cindy E. Fishman,Cynthia DeLong,Pedro Piccardo,Valérie Petegnief,Bernardino Ghetti,Steven M. Paul +12 more
TL;DR: It is postulated that apoE promotes both the deposition and fibrillization of Abeta, ultimately affecting clearance of protease-resistant Abeta/apoE aggregates.
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Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment.
Harald Hampel,Stefan J. Teipel,T. Fuchsberger,Niels Andreasen,Jens Wiltfang,Markus Otto,Yong Shen,Richard Dodel,Yansheng Du,Martin R. Farlow,H.-J. Möller,Kaj Blennow,Katharina Buerger +12 more
TL;DR: Findings support the notion that CSF tau and Aβ1–42 may be useful biomarkers in the early identification of AD in MCI subjects.
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α2-Macroglobulin Attenuates β-Amyloid Peptide 1–40 Fibril Formation and Associated Neurotoxicity of Cultured Fetal Rat Cortical Neurons
Yansheng Du,Kelly R. Bales,Richard C. Dodel,Richard C. Dodel,Xiaodong Liu,Michele A. Glinn,Jeffrey W. Horn,Sheila P. Little,Steven M. Paul +8 more
TL;DR: It is reported that, in contrast to another plaque‐associated protein, α1‐antichymotrypsin, α2M coincubated with Aβ significantly reduces aggregation and fibril formation in vitro, and cultured fetal rat cortical neurons are less vulnerable to the toxic actions of aged Aβ following pretreatment withα2M.
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Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death.
Richard C. Dodel,Yansheng Du,Kelly R. Bales,Zaodong Ling,Paul M. Carvey,Steven M. Paul,Steven M. Paul +6 more
TL;DR: 6-OHDA-induced apoptosis of CGN involves activation of a caspase-3-like protease, in contrast to the neurotoxicity induced by MPP+, however, the peptide inhibitors zVAD-FMK and Ac-DEVD-CHO can only attenuate early neuronal death induced by 6-OHda.