V
Valery Combes
Researcher at University of Technology, Sydney
Publications - 85
Citations - 6217
Valery Combes is an academic researcher from University of Technology, Sydney. The author has contributed to research in topics: Cerebral Malaria & Endothelium. The author has an hindex of 40, co-authored 84 publications receiving 5665 citations. Previous affiliations of Valery Combes include University of Sydney & Centre national de la recherche scientifique.
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Journal ArticleDOI
In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
Valery Combes,Anne Christine Simon,Georges E. Grau,D. Arnoux,Laurence Camoin,Florence Sabatier,Murielle Mutin,Marielle Sanmarco,José Sampol,Françoise Dignat-George +9 more
TL;DR: Examination of morphological, immunological, and functional characteristics of MPs derived from human umbilical vein endothelial cells stimulated by TNF provides evidence that endothelial-derived MPs are detectable in normal human blood and are increased in patients with a coagulation abnormality characterized by the presence of lupus anticoagulant.
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Type 1 and type 2 diabetic patients display different patterns of cellular microparticles.
Florence Sabatier,Patrice Darmon,Bénédicte Hugel,Valery Combes,Marielle Sanmarco,JG Velut,D. Arnoux,Phillipe Charpiot,Jean-Marie Freyssinet,Charles Oliver,José Sampol,Françoise Dignat-George +11 more
TL;DR: Results showed that a wide vesiculation process, resulting from activation or apoptosis of several cell types, occurs in diabetes, however, diabetic patients differ by the procoagulant activity and the cellular origin of microparticles.
Journal ArticleDOI
A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction
TL;DR: The events resulting in the development of cerebral malaria complications are multi-factorial, encompassing a dynamic interaction between three processes, thereby explaining the complexity of this deadly syndrome.
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Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells.
TL;DR: It is established that MPs shed in vitro from drug-resistant cancer cells incorporate cell surface P- gp from their donor cells, effectively bind to drug-sensitive recipient cells and transfer functional P-gp to the latter.
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Endothelial microparticles: a potential contribution to the thrombotic complications of the antiphospholipid syndrome.
Françoise Dignat-George,Laurence Camoin-Jau,Florence Sabatier,D. Arnoux,Francine Anfosso,Nathalie Bardin,Véronique Veit,Valery Combes,Stéphanie Gentile,Valérie Moal,Marielle Sanmarco,José Sampol +11 more
TL;DR: Ex vivo and in vitro observations indicate that generation of EMP in APS and SLE patients results from an autoimmune process involving aPL, which may represent a new pathogenic mechanism for the thrombotic complications of this disease.