V
Valeryia Mikalayeva
Researcher at Lithuanian University of Health Sciences
Publications - 12
Citations - 133
Valeryia Mikalayeva is an academic researcher from Lithuanian University of Health Sciences. The author has contributed to research in topics: Efflux & Cancer cell. The author has an hindex of 5, co-authored 11 publications receiving 90 citations. Previous affiliations of Valeryia Mikalayeva include Vytautas Magnus University.
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Journal ArticleDOI
Genome scale metabolic models as tools for drug design and personalized medicine.
Vytautas Raškevičius,Vytautas Raškevičius,Valeryia Mikalayeva,Ieva Antanavičiūtė,Ieva Ceslevičienė,Vytenis Arvydas Skeberdis,Visvaldas Kairys,Sergio Bordel,Sergio Bordel +8 more
TL;DR: It was predicted that the mevalonate pathway might constitute a good therapeutic window against cancer proliferation, due to the fact that most cancer cell lines do not express the cholesterol transporter NPC1L1 and the lipoprotein lipase LPL, which makes them rely on the mevalsenate pathway to obtain cholesterol.
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Fatty Acid Synthesis and Degradation Interplay to Regulate the Oxidative Stress in Cancer Cells.
Valeryia Mikalayeva,Ieva Ceslevičienė,Ieva Sarapinienė,Vaidotas Žvikas,Vytenis Arvydas Skeberdis,Valdas Jakštas,Sergio Bordel +6 more
TL;DR: This study aimed to confirm experimentally whether FAS and FAO coexist in breast cancer cells (BCC), and showed that part of the cytosolic acetyl-CoA used in lipid synthesis is also fed back into the mitochondrion via fatty acid degradation.
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Application of holographic sub-wavelength diffraction gratings for monitoring of kinetics of bioprocesses
Tomas Tamulevičius,Rimas Šeperys,Mindaugas Andrulevičius,V. Kopustinskas,Šarūnas Meškinis,Sigitas Tamulevičius,Valeryia Mikalayeva,Rimantas Daugelavičius +7 more
TL;DR: In this article, the authors presented a refractive index (RI) sensor based on a sub-wavelength holographic diffraction grating, which was fabricated by dry etching of the finely spaced (d ǫ = 428 Ã − 4 n) diffraction surface in SiO x doped diamond like carbon (DLC) film.
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Femtosecond laser micro-machined polyimide films for cell scaffold applications
Ieva Antanavičiūtė,Linas Šimatonis,Orestas Ulčinas,Aušra Gadeikytė,Brigita Abakevičienė,Sigitas Tamulevičius,Valeryia Mikalayeva,Vytenis Arvydas Skeberdis,Edgaras Stankevičius,Tomas Tamulevičius +9 more
TL;DR: It is demonstrated that virgin PI films provide a suitable environment for the mobility, proliferation and intercellular communication of human bone marrow mesenchymal stem cells, and how cell behaviour varies on the micro‐machined PI films with holes of different diameters is discussed.
Journal ArticleDOI
Transcriptional hallmarks of cancer cell lines reveal an emerging role of branched chain amino acid catabolism
Ieva Antanavičiūtė,Valeryia Mikalayeva,Ieva Ceslevičienė,Gintarė Milašiūtė,Vytenis Arvydas Skeberdis,Sergio Bordel,Sergio Bordel +6 more
TL;DR: A comparative analysis between cancer cell lines and healthy dividing cells was performed and it was shown that the epithelial-mesenchymal transition was associated with the up-regulation of 5 enzymes involved in the degradation of branched chain amino acids.