V
Vamsi Mangena
Researcher at Massachusetts Institute of Technology
Publications - 3
Citations - 804
Vamsi Mangena is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Proteome & Protein subcellular localization prediction. The author has an hindex of 3, co-authored 3 publications receiving 532 citations.
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Journal ArticleDOI
Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition
Anthony J Martorell,Anthony J Martorell,Abigail L. Paulson,Ho-Jun Suk,Ho-Jun Suk,Fatema Abdurrob,Fatema Abdurrob,Gabrielle T. Drummond,Gabrielle T. Drummond,Webster Guan,Jennie Z. Young,Jennie Z. Young,David Nam Woo Kim,David Nam Woo Kim,Oleg Kritskiy,Oleg Kritskiy,Scarlett J. Barker,Scarlett J. Barker,Vamsi Mangena,Stephanie M. Prince,Emery N. Brown,Kwanghun Chung,Edward S. Boyden,Edward S. Boyden,Annabelle C. Singer,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: Auditory tone stimulation that drove gamma frequency neural activity in auditory cortex (AC) and hippocampal CA1 improved spatial and recognition memory and reduced amyloid in AC and hippocampus of 5XFAD mice, suggesting GENUS can be achieved through multiple sensory modalities with wide-ranging effects across multiple brain areas to improve cognitive function.
Journal ArticleDOI
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues.
Taeyun Ku,Taeyun Ku,Justin Swaney,Jeong Yoon Park,Jeong Yoon Park,Jeong Yoon Park,Alexandre Albanese,Evan Murray,Jae Hun Cho,Young Gyun Park,Young Gyun Park,Vamsi Mangena,Jiapei Chen,Kwanghun Chung +13 more
TL;DR: A method for super-resolution imaging of the multiscale organization of intact tissues, called magnified analysis of the proteome (MAP), linearly expands entire organs fourfold while preserving their overall architecture and three-dimensional proteome organization.
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues
Taeyun Ku,Taeyun Ku,Justin Swaney,Jeong Yoon Park,Jeong Yoon Park,Jeong Yoon Park,Alexandre Albanese,Evan Murray,Jae Hun Cho,Young Gyun Park,Young Gyun Park,Vamsi Mangena,Jiapei Chen,Kwanghun Chung +13 more
TL;DR: Magnified analysis of the proteome (MAP) as mentioned in this paper is based on the observation that preventing crosslinking within and between endogenous proteins during hydrogel-tissue hybridization allows for natural expansion upon protein denaturation and dissociation.