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Anthony J Martorell
Researcher at Picower Institute for Learning and Memory
Publications - 21
Citations - 3819
Anthony J Martorell is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Synaptic plasticity & Synaptic vesicle. The author has an hindex of 13, co-authored 21 publications receiving 2324 citations. Previous affiliations of Anthony J Martorell include Massachusetts Institute of Technology & University of Tampa.
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Journal ArticleDOI
Single-cell transcriptomic analysis of Alzheimer’s disease
Hansruedi Mathys,Hansruedi Mathys,Jose Davila-Velderrain,Jose Davila-Velderrain,Zhuyu Peng,Zhuyu Peng,Fan Gao,Fan Gao,Shahin Mohammadi,Shahin Mohammadi,Jennie Z. Young,Jennie Z. Young,Madhvi Menon,Madhvi Menon,Liang He,Liang He,Fatema Abdurrob,Fatema Abdurrob,Xueqiao Jiang,Xueqiao Jiang,Anthony J Martorell,Anthony J Martorell,Richard M. Ransohoff,Brian P. Hafler,David A. Bennett,Manolis Kellis,Manolis Kellis,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +29 more
TL;DR: Single-cell transcriptomics from 48 individuals with varying degrees of Alzheimer's disease pathology demonstrates that gene-expression changes in Alzheimer’s disease are both cell-type specific and shared, and that transcriptional responses show sexual dimorphism.
Journal ArticleDOI
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Hannah Iaccarino,Annabelle C. Singer,Anthony J Martorell,Anthony J Martorell,Andrii Rudenko,Andrii Rudenko,Fan Gao,Fan Gao,Tyler Z. Gillingham,Tyler Z. Gillingham,Hansruedi Mathys,Hansruedi Mathys,Jinsoo Seo,Jinsoo Seo,Oleg Kritskiy,Oleg Kritskiy,Fatema Abdurrob,Fatema Abdurrob,Chinnakkaruppan Adaikkan,Chinnakkaruppan Adaikkan,Rebecca G. Canter,Rebecca G. Canter,Richard Rueda,Richard Rueda,Emery N. Brown,Edward S. Boyden,Edward S. Boyden,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +29 more
TL;DR: Reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology.
Journal ArticleDOI
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies
Paul W. Tillberg,Fei Chen,Kiryl D. Piatkevich,Yongxin Zhao,Chih-Chieh Yu,Brian P. English,Linyi Gao,Anthony J Martorell,Ho-Jun Suk,Fumiaki Yoshida,Fumiaki Yoshida,Ellen M DeGennaro,Douglas H. Roossien,Guanyu Gong,Uthpala Seneviratne,Steven R. Tannenbaum,Robert Desimone,Dawen Cai,Edward S. Boyden +18 more
TL;DR: ProExM as mentioned in this paper is a variant of ExM in which proteins are anchored to the swellable gel, allowing the use of conventional fluorescently labeled antibodies and streptavidin, and fluorescent proteins.
Journal ArticleDOI
Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition
Anthony J Martorell,Anthony J Martorell,Abigail L. Paulson,Ho-Jun Suk,Ho-Jun Suk,Fatema Abdurrob,Fatema Abdurrob,Gabrielle T. Drummond,Gabrielle T. Drummond,Webster Guan,Jennie Z. Young,Jennie Z. Young,David Nam Woo Kim,David Nam Woo Kim,Oleg Kritskiy,Oleg Kritskiy,Scarlett J. Barker,Scarlett J. Barker,Vamsi Mangena,Stephanie M. Prince,Emery N. Brown,Kwanghun Chung,Edward S. Boyden,Edward S. Boyden,Annabelle C. Singer,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: Auditory tone stimulation that drove gamma frequency neural activity in auditory cortex (AC) and hippocampal CA1 improved spatial and recognition memory and reduced amyloid in AC and hippocampus of 5XFAD mice, suggesting GENUS can be achieved through multiple sensory modalities with wide-ranging effects across multiple brain areas to improve cognitive function.
Journal ArticleDOI
Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Hannah Iaccarino,Annabelle C. Singer,Anthony J Martorell,Anthony J Martorell,Andrii Rudenko,Andrii Rudenko,Andrii Rudenko,Fan Gao,Fan Gao,Tyler Z. Gillingham,Tyler Z. Gillingham,Hansruedi Mathys,Hansruedi Mathys,Jinsoo Seo,Jinsoo Seo,Oleg Kritskiy,Oleg Kritskiy,Fatema Abdurrob,Fatema Abdurrob,Chinnakkaruppan Adaikkan,Chinnakkaruppan Adaikkan,Rebecca G. Canter,Rebecca G. Canter,Richard Rueda,Richard Rueda,Emery N. Brown,Edward S. Boyden,Edward S. Boyden,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +30 more
TL;DR: Reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer’s disease uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology.