V
Vanessa Lemahieu
Researcher at Stanford University
Publications - 4
Citations - 1057
Vanessa Lemahieu is an academic researcher from Stanford University. The author has contributed to research in topics: Wiskott–Aldrich syndrome protein & Gene. The author has an hindex of 4, co-authored 4 publications receiving 1035 citations.
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Journal ArticleDOI
Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization
Marc Symons,Jonathan M.J. Derry,Brian Karlak,Sharon Jiang,Vanessa Lemahieu,Frank McCormick,Uta Francke,Uta Francke,Arie Abo +8 more
TL;DR: WAS provides a novel link between CDC42Hs and the actin cytoskeleton, which suggests a molecular mechanism for many of the cellular abnormalities in WAS.
Journal ArticleDOI
Manifestations and linkage analysis in X-linked autoimmunity-immunodeficiency syndrome.
Polly J. Ferguson,Susan H. Blanton,Frank T. Saulsbury,Marcia McDuffie,Vanessa Lemahieu,Julie M. Gastier,Uta Francke,Stephen M. Borowitz,James L. Sutphen,Thaddeus E. Kelly +9 more
TL;DR: It is concluded that this kindred has an X-linked disorder, distinct from WAS, that results in autoimmunity and variable immunodeficiency, which includes the Wiskott-Aldrich syndrome locus.
Journal ArticleDOI
Novel mutations in the Wiskott-Aldrich syndrome protein gene and their effects on transcriptional, translational, and clinical phenotypes.
TL;DR: It is concluded that mutation analysis at the DNA level is not sufficient for predicting clinical course and studies at the transcript and protein level are needed for a better assessment.
Journal ArticleDOI
The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome
Jonathan M.J. Derry,Philipp Wiedemann,Patrick Blair,Yu-Ker Wang,Julie A. Kerns,Vanessa Lemahieu,V. L. Godfrey,Erby Wilkinson,Erby Wilkinson,Uta Francke +9 more
TL;DR: Northern analysis of sf tissue samples indicated the presence of WASP mRNA in liver and skin, presumably as a consequence of lymphocytic infiltration, but non abnormalities in the amount or size of mRNA present.