V
Vanessa M. D'Costa
Researcher at McMaster University
Publications - 8
Citations - 3848
Vanessa M. D'Costa is an academic researcher from McMaster University. The author has contributed to research in topics: Antibiotic resistance & Resistome. The author has an hindex of 8, co-authored 8 publications receiving 3289 citations.
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Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
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Sampling the Antibiotic Resistome
TL;DR: This work has shown that soil-dwelling bacteria are a reservoir of resistance determinants that can be mobilized into the microbial community, and study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.
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Expanding the soil antibiotic resistome: exploring environmental diversity.
TL;DR: An unexpected density of resistance genes in the environment: the antibiotic resistome is revealed, which challenges the current understanding of antibiotic resistance and provides both barriers and opportunities for antimicrobial drug discovery.
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Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7.
Vanessa M. D'Costa,Virginie Braun,Marija Landekic,Rong Shi,A. Proteau,Laura McDonald,Miroslaw Cygler,Miroslaw Cygler,Sergio Grinstein,John H. Brumell +9 more
TL;DR: This study identifies a bacterial effector capable of directly binding and thereby modulating Rab7 activity and a mechanism of endocytic trafficking disruption that may provide insight into the pathogenesis of other bacteria.
Journal ArticleDOI
Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms
Vanessa M. D'Costa,Tariq A. Mukhtar,Tejal Patel,Kalinka Koteva,Nicholas Waglechner,Donald W. Hughes,Gerard D. Wright,Gianfranco De Pascale +7 more
TL;DR: These findings represent the first comprehensive characterization of daptomycin inactivation in any bacterial class and may not only presage a future mechanism of clinical resistance but also suggest strategies for the development of new lipopeptides.