L
Lindsay Kalan
Researcher at University of Wisconsin-Madison
Publications - 48
Citations - 4945
Lindsay Kalan is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 18, co-authored 34 publications receiving 3729 citations. Previous affiliations of Lindsay Kalan include McMaster University & University of Pennsylvania.
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Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
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The Comprehensive Antibiotic Resistance Database
Andrew G. McArthur,Nicholas Waglechner,Fazmin Nizam,Austin Yan,Marisa A. Azad,Alison J. Baylay,Kirandeep Bhullar,Marc J. Canova,Gianfranco De Pascale,Linda Ejim,Lindsay Kalan,Andrew M. King,Kalinka Koteva,Mariya Morar,Michael R. Mulvey,Jonathan S O'Brien,Andrew C. Pawlowski,Laura J. V. Piddock,Peter Spanogiannopoulos,Arlene D. Sutherland,Irene Tang,Patricia L. Taylor,Maulik N. Thaker,Wenliang Wang,Marie Yan,Tennison Yu,Gerard D. Wright +26 more
TL;DR: The CARD integrates disparate molecular and sequence data, provides a unique organizing principle in the form of the Antibiotic Resistance Ontology (ARO), and can quickly identify putative antibiotic resistance genes in new unannotated genome sequences.
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Antibiotic adjuvants: multicomponent anti-infective strategies
Lindsay Kalan,Gerard D. Wright +1 more
TL;DR: The current situation and potential drug combinations that may increase the potency of antibiotics in the future are reviewed and a rationale for these multicomponent strategies is provided.
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Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing
Lindsay Kalan,Michael A. Loesche,Brendan P. Hodkinson,Kristopher P. Heilmann,Gordon Ruthel,Sue E. Gardner,Elizabeth A. Grice +6 more
TL;DR: It is shown for the first time that fungal communities (the mycobiome) in chronic wounds are predictive of healing time, associated with poor outcomes, and form mixed fungal-bacterial biofilms.
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Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing
Michael A. Loesche,Sue E. Gardner,Lindsay Kalan,Joseph Horwinski,Qi Zheng,Brendan P. Hodkinson,Amanda S. Tyldsley,Carrie L. Franciscus,Stephen L. Hillis,Samir Mehta,David J. Margolis,Elizabeth A. Grice +11 more
TL;DR: Evidence is provided that the dynamic wound microbiome is indicative of clinical outcomes and may be a valuable guide for personalized management and treatment of chronic wounds.