R
Régis Debruyne
Researcher at Centre national de la recherche scientifique
Publications - 29
Citations - 3048
Régis Debruyne is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Woolly mammoth & Mammoth. The author has an hindex of 18, co-authored 29 publications receiving 2583 citations. Previous affiliations of Régis Debruyne include University of California, San Diego & McMaster University.
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Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
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New insights from old bones: DNA preservation and degradation in permafrost preserved mammoth remains
Carsten Schwarz,Régis Debruyne,Melanie Kuch,Elizabeth A. McNally,Henry P. Schwarcz,Andrew D. Aubrey,Jeffrey L. Bada,Hendrik N. Poinar +7 more
TL;DR: The initial DNA concentration in the bone tissue is found to be as relevant for the total accessible mitochondrial DNA as the extent of DNA degradation post-mortem, and there is evidence suggesting that mitochondrial DNA is better preserved than nuclear DNA in ancient permafrost samples.
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Out of America: Ancient DNA Evidence for a New World Origin of Late Quaternary Woolly Mammoths
Régis Debruyne,Genevieve Chu,Christine E. King,Kirsti Bos,Melanie Kuch,Carsten Schwarz,Paul Szpak,Darren R. Gröcke,Paul Matheus,Grant D. Zazula,Dale Guthrie,Duane G. Froese,Bernard Buigues,Christian de Marliave,Clare Flemming,Debi Poinar,Daniel C. Fisher,John Southon,Alexei Tikhonov,Ross D. E. MacPhee,Hendrik N. Poinar +20 more
TL;DR: The "Out-of-America" hypothesis holds that the dispersal of North American woolly mammoths into other parts of Holarctica created major phylogeographic structuring within Mammuthus primigenius populations, shaping the last phase of their evolutionary history before their demise.
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A quantitative approach to detect and overcome PCR inhibition in ancient DNA extracts.
TL;DR: Although some trends were apparent within sample types, differences in inhibition levels, optimal reactions conditions, and expected recovery of DNA under these conditions suggest that all samples be routinely tested with this approach.
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Regional differences in bone collagen δ13C and δ15N of Pleistocene mammoths: Implications for paleoecology of the mammoth steppe
Paul Szpak,Darren R. Gröcke,Régis Debruyne,Ross D. E. MacPhee,R. Dale Guthrie,Duane G. Froese,Grant D. Zazula,William P. Patterson,Hendrik N. Poinar +8 more
TL;DR: In this paper, the authors present bone collagen δ13C and δ15N values from a large set of Pleistocene woolly mammoths (Mammuthus primigenius) from Siberia, Alaska and Yukon.