Vangipuram S. Rangan

TL;DR: The data permit refinement of the model for the fatty-acid synthase dimer and suggest that the malonyl/acetyl transferase and oxoacyl synthase of one subunit cooperate with the reductases, acyl carrier protein and thioesterase of the companion subunit in the formation of a center for fatty- acid synthesis.

TL;DR: A single candidate 4′-phosphopantetheine transferase, identified by BLAST searches of the human genome sequence data base, has been cloned, expressed, and characterized and appears to utilize a single, broad specificity enzyme for all posttrans lysine catabolism reactions.

TL;DR: Results, taken together with previous studies, identify a region on Nef critical for most of its known functions, however, not all Nef alleles bind to hTE with high affinity, so the role of hTE during HIV infection remains uncertain.

TL;DR: The results suggest that essential to the regulation of FAS transcription by cAMP is the interaction of an inverted CCAAT box motif with a constitutively produced trans-acting factor that either itself undergoes modification in response to cAMP or associates with a protein that is produced or modified bycAMP exposure.

TL;DR: The results are consistent with a model for the fatty acid synthase in which the substrate loading and condensation reactions are catalyzed by cooperation of an acyl carrier protein domain of one subunit with the malonyl/acetyltransferase or beta-ketoacyl synthase domains, respectively, of either subunit.