Varda Negreanu

TL;DR: The data indicate that cytokine gene expression in TH1 cells may be controlled by a feed-forward regulatory circuit in which T-bet induces Runx3 and then 'partners' with Runx 3 to direct lineage-specific gene activation and silencing.

TL;DR: It is shown that Runx3‐deficient mice develop severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneurons, and the underlying cause is a loss of DRG proprioceptive neurons.

TL;DR: Analysis of AML1 and AML2 expression in hematopoietic cell lines revealed a distinct pattern of expression, and their C-terminal halves were particularly rich in proline and serine residues.

TL;DR: It is reported that Runx3 and Runx1 are highly expressed in thymic medulla and cortex, respectively, and function in development of CD8 T cells during thymopoiesis and suggest that both act as transcriptional repressors of CD4 expression during T cell lineage decisions.

TL;DR: It is reported that Runx3 knockout (KO) mice develop spontaneous eosinophilic lung inflammation associated with airway remodeling and mucus hypersecretion, which may help elucidate the molecular mechanisms underlying the pathogenesis of allergic airway inflammation in humans.