Yael Bernstein

TL;DR: It is shown that AML1 and LEF-1 can act, through recruitment of the corepressor TLE1, as transcriptional repressors in TCR regulation and Wnt/Wg signaling.

TL;DR: It is shown that Runx3‐deficient mice develop severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneurons, and the underlying cause is a loss of DRG proprioceptive neurons.

TL;DR: Analysis of AML1 and AML2 expression in hematopoietic cell lines revealed a distinct pattern of expression, and their C-terminal halves were particularly rich in proline and serine residues.

TL;DR: It is reported that Runx3 and Runx1 are highly expressed in thymic medulla and cortex, respectively, and function in development of CD8 T cells during thymopoiesis and suggest that both act as transcriptional repressors of CD4 expression during T cell lineage decisions.

TL;DR: Human and mouse cell clones that overproduce the hSOD‐1 had altered properties; they were more resistant to paraquat than the parental cells and showed an increase in lipid peroxidation, consistent with the possibility that gene dosage of hS OD‐1 contributes to some of the clinical symptoms associated with Down's syndrome.