V
Vasanthy Narayanaswami
Researcher at California State University, Long Beach
Publications - 40
Citations - 1716
Vasanthy Narayanaswami is an academic researcher from California State University, Long Beach. The author has contributed to research in topics: Apolipoprotein E & Apolipoprotein B. The author has an hindex of 14, co-authored 35 publications receiving 1490 citations. Previous affiliations of Vasanthy Narayanaswami include Children's Hospital Oakland & Children's Hospital Oakland Research Institute.
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Journal ArticleDOI
Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide.
Emilie Cerf,Rabia Sarroukh,Shiori Tamamizu-Kato,Leonid Breydo,Sylvie Derclaye,Yves F. Dufrêne,Vasanthy Narayanaswami,Vasanthy Narayanaswami,Erik Goormaghtigh,Jean Marie Ruysschaert,Vincent Raussens +10 more
TL;DR: The results are discussed in terms of a possible organization of the antiparallel beta-sheets in Abeta oligomers, which may be related to reported effects of these highly toxic species in the amyloid pathogenesis associated with AD.
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Apolipoprotein E: from lipid transport to neurobiology.
TL;DR: Apolipoprotein (apo) E is described through a lens of structure-based knowledge that leads to hypotheses that attempt to explain the functions of apoE and isoform-specific effects relating to disease mechanism.
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Pyrene: a probe to study protein conformation and conformational changes
TL;DR: The review focuses on the unique spectral features of pyrene that can be utilized to investigate protein structure and conformation as well as monitoring protein conformation, conformational changes, protein folding and unfolding, protein-protein,protein-lipid and protein-membrane interactions.
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The extent of pyrene excimer fluorescence emission is a reflector of distance and flexibility: analysis of the segment linking the LDL receptor-binding and tetramerization domains of apolipoprotein E3.
TL;DR: The use of pyrene as a powerful probe for studying protein spatial organization is presented and it is inferred that oligomerization via the C-terminal domain juxtaposes the linker segments from neighboring apoE molecules.
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A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice
John K. Bielicki,Haiyan Zhang,Yuan Cortez,Ying Zheng,Vasanthy Narayanaswami,Arti B. Patel,Jan Johansson,Salman Azhar +7 more
TL;DR: In this paper, a single-helix pep tide (ATI-5261) was used to stimulate cellular cholesterol effliency with K m molar effi ciency approximating native apolipoproteins.