V
Vassily Hatzimanikatis
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 199
Citations - 11093
Vassily Hatzimanikatis is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Metabolic network & Flux balance analysis. The author has an hindex of 53, co-authored 185 publications receiving 9749 citations. Previous affiliations of Vassily Hatzimanikatis include DuPont Central Research & University of Patras.
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A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information.
Adam M. Feist,Christopher S. Henry,Jennifer L. Reed,Markus Krummenacker,Andrew R. Joyce,Peter D. Karp,Linda J. Broadbelt,Vassily Hatzimanikatis,Bernhard O. Palsson +8 more
TL;DR: An updated genome‐scale reconstruction of the metabolic network in Escherichia coli K‐12 MG1655 with increased scope and computational capability is presented, expected to broaden the spectrum of both basic biology and applied systems biology studies of E. coli metabolism.
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Thermodynamics-Based Metabolic Flux Analysis
TL;DR: A significant number of reactions appear to be the first steps in the linear portion of numerous biosynthesis pathways and might be candidates for cell regulation, and it is found that the NAD/NADH and NADP/NadPH ratios maintained in the cell are close to the minimum feasible ratio and maximum feasible ratio, respectively.
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Group Contribution Method for Thermodynamic Analysis of Complex Metabolic Networks
TL;DR: This group contribution method is demonstrated to be capable of estimating Delta(r)G'(o) and Delta(f)G (o) for the majority of the biochemical compounds and reactions found in the iJR904 and iAF1260 genome-scale metabolic models of Escherichia coli and in the Kyoto Encyclopedia of Genes and Genomes and University of Minnesota Biocatalysis and Biodegradation Database.
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Exploring the diversity of complex metabolic networks
Vassily Hatzimanikatis,Chunhui Li,Justin A. Ionita,Christopher S. Henry,Matthew D. Jankowski,Linda J. Broadbelt +5 more
TL;DR: A computational approach for the identification of every possible biochemical reaction from a given set of enzyme reaction rules that allows the de novo synthesis of metabolic pathways composed of these reactions, and the evaluation of these novel pathways with respect to their thermodynamic properties is described.
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Metabolic flux analysis of hybridoma cells in different culture media using mass balances.
H.P.J. Bonarius,Vassily Hatzimanikatis,K. P. H. Meesters,C.D. de Gooijer,Georg Schmid,Johannes Tramper +5 more
TL;DR: The flux distribution that is found using the Euclidean minimum norm as the additional theoretical constraint and taking either the CO2 or the NAD(P)H mass balance into account is shown to be in agreement with the measured O2 and CO2 metabolic rates.