V
Viachaslau Bernat
Researcher at Scripps Research Institute
Publications - 9
Citations - 998
Viachaslau Bernat is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Allosteric regulation & Docking (molecular). The author has an hindex of 7, co-authored 9 publications receiving 788 citations. Previous affiliations of Viachaslau Bernat include University of Erlangen-Nuremberg.
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Journal ArticleDOI
Structure-based discovery of opioid analgesics with reduced side effects
Aashish Manglik,Henry Lin,Dipendra K. Aryal,John D. McCorvy,Daniela Dengler,Gregory Corder,Anat Levit,Ralf C. Kling,Ralf C. Kling,Viachaslau Bernat,Harald Hübner,Xi Ping Huang,Maria F. Sassano,Patrick M. Giguère,Stefan Löber,Da Duan,Grégory Scherrer,Brian K. Kobilka,Peter Gmeiner,Bryan L. Roth,Brian K. Shoichet +20 more
TL;DR: PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment and is devoid of both respiratory depression and morphine-like reinforcing activity in mice at equi-analgesic doses.
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RNA Structures as Mediators of Neurological Diseases and as Drug Targets
TL;DR: This Review provides a brief introduction into RNA structural biology and describes how RNA structures function in cells and cause or contribute to neurological disease, and demonstrates successful applications of rational design principles to provide chemical probes and lead compounds targeting structured RNAs.
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The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.
Zi-Fu Wang,Andrei Ursu,Jessica L. Childs-Disney,Rea Guertler,Wang Yong Yang,Viachaslau Bernat,Suzanne G. Rzuczek,Rita Fuerst,Yong Jie Zhang,Tania F. Gendron,Ilyas Yildirim,Brendan G. Dwyer,Joseph E. Rice,Leonard Petrucelli,Matthew D. Disney +14 more
TL;DR: It is highlighted that the hairpin structure of r(G4C2)exp is a therapeutically relevant target and small molecules that bind it can ameliorate c9ALS/FTD-associated toxicity.
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Identifying Modulators of CXC Receptors 3 and 4 with Tailored Selectivity Using Multi-Target Docking
TL;DR: Docking is a suitable tool for the identification of ligands with tailored binding profiles to GPCRs, even when using homology models, and novel CXCR3-CXCR4 dual modulators are presented that might pave the road to understanding the mechanisms of polypharmacological inhibition of these receptors.
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Boronic Acids as Probes for Investigation of Allosteric Modulation of the Chemokine Receptor CXCR3
TL;DR: The data demonstrate that boronic acid derivatives represent an outstanding tool for determination of key receptor-ligand interactions and induction of ligand-biased signaling.