G
Gregory Corder
Researcher at University of Pennsylvania
Publications - 28
Citations - 2130
Gregory Corder is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Opioid & Medicine. The author has an hindex of 12, co-authored 21 publications receiving 1542 citations. Previous affiliations of Gregory Corder include University of Kentucky & Stanford University.
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Journal ArticleDOI
Structure-based discovery of opioid analgesics with reduced side effects
Aashish Manglik,Henry Lin,Dipendra K. Aryal,John D. McCorvy,Daniela Dengler,Gregory Corder,Anat Levit,Ralf C. Kling,Ralf C. Kling,Viachaslau Bernat,Harald Hübner,Xi Ping Huang,Maria F. Sassano,Patrick M. Giguère,Stefan Löber,Da Duan,Grégory Scherrer,Brian K. Kobilka,Peter Gmeiner,Bryan L. Roth,Brian K. Shoichet +20 more
TL;DR: PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment and is devoid of both respiratory depression and morphine-like reinforcing activity in mice at equi-analgesic doses.
Journal ArticleDOI
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Gregory Corder,Vivianne L. Tawfik,Dong Wang,Elizabeth I. Sypek,Sarah A. Low,Jasmine R. Dickinson,Chaudy Sotoudeh,J. David Clark,Ben A. Barres,Christopher J. Bohlen,Grégory Scherrer +10 more
TL;DR: The data support the idea that opioid agonists can be combined with peripheral MOR antagonists to limit analgesic tolerance and OIH in perioperative and chronic pain models.
Journal ArticleDOI
Endogenous and Exogenous Opioids in Pain.
TL;DR: This review describes the functional organization and pharmacology of the endogenous opioid system and discusses the loci of opioid analgesic action along peripheral and central pain pathways, emphasizing the pain-relieving properties of opioids against the affective dimension of the pain experience.
PatentDOI
Amygdalar neural ensemble that encodes the unpleasantness of pain
Grégory Scherrer,Mark J. Schnitzer,Benjamin F. Grewe,Dong Wang,Biafra Ahanonu,Biafra Ahanonu,Gregory Corder +6 more
TL;DR: These results identify the amygdalar representations of noxious stimuli that are functionally required for the negative affective qualities of acute and chronic pain perception.
Journal ArticleDOI
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Gregory Corder,Suzanne Doolen,Renee R. Donahue,Michele K Winter,Brandon L. Jutras,Y He,Xiaoyu Hu,Joseph S Wieskopf,Jeffrey S. Mogil,Daniel R. Storm,Z J Wang,Kenneth E. McCarson,Bradley K. Taylor +12 more
TL;DR: The results suggest that constitutive activation of µ-opioid receptors depresses nociception for long periods of time and induces cellular and physical dependence on endogenous opioid signaling and MORCA initiates both analgesic signaling and a compensatory opponent process that generates endogenous opioid dependence.