G
Grégory Scherrer
Researcher at Stanford University
Publications - 55
Citations - 7787
Grégory Scherrer is an academic researcher from Stanford University. The author has contributed to research in topics: Opioid & δ-opioid receptor. The author has an hindex of 29, co-authored 44 publications receiving 6325 citations. Previous affiliations of Grégory Scherrer include French Institute of Health and Medical Research & University of California, San Francisco.
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Journal ArticleDOI
Cellular and Molecular Mechanisms of Pain
TL;DR: Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.
Journal ArticleDOI
Structure-based discovery of opioid analgesics with reduced side effects
Aashish Manglik,Henry Lin,Dipendra K. Aryal,John D. McCorvy,Daniela Dengler,Gregory Corder,Anat Levit,Ralf C. Kling,Ralf C. Kling,Viachaslau Bernat,Harald Hübner,Xi Ping Huang,Maria F. Sassano,Patrick M. Giguère,Stefan Löber,Da Duan,Grégory Scherrer,Brian K. Kobilka,Peter Gmeiner,Bryan L. Roth,Brian K. Shoichet +20 more
TL;DR: PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment and is devoid of both respiratory depression and morphine-like reinforcing activity in mice at equi-analgesic doses.
Journal ArticleDOI
Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.
Grégory Scherrer,Noritaka Imamachi,Yu-Qing Cao,Candice Contet,Françoise Mennicken,Dajan O'Donnell,Brigitte L. Kieffer,Allan I. Basbaum +7 more
TL;DR: It is shown that the segregated DOR and MOR distribution is paralleled by a remarkably selective functional contribution of the two receptors to the control of mechanical and heat pain, respectively.
Journal ArticleDOI
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Gregory Corder,Vivianne L. Tawfik,Dong Wang,Elizabeth I. Sypek,Sarah A. Low,Jasmine R. Dickinson,Chaudy Sotoudeh,J. David Clark,Ben A. Barres,Christopher J. Bohlen,Grégory Scherrer +10 more
TL;DR: The data support the idea that opioid agonists can be combined with peripheral MOR antagonists to limit analgesic tolerance and OIH in perioperative and chronic pain models.
Journal ArticleDOI
Endogenous and Exogenous Opioids in Pain.
TL;DR: This review describes the functional organization and pharmacology of the endogenous opioid system and discusses the loci of opioid analgesic action along peripheral and central pain pathways, emphasizing the pain-relieving properties of opioids against the affective dimension of the pain experience.