V
Victor J. Lotti
Researcher at Merck & Co.
Publications - 94
Citations - 4376
Victor J. Lotti is an academic researcher from Merck & Co.. The author has contributed to research in topics: Cholecystokinin & Receptor. The author has an hindex of 27, co-authored 94 publications receiving 4251 citations. Previous affiliations of Victor J. Lotti include United States Military Academy.
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Journal ArticleDOI
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: 3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.
Journal ArticleDOI
Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist
TL;DR: L-364,718 exhibited a very high selectivity for peripheral CCK receptors relative to brain CCK, gastrin, and various other peptide and nonpeptide receptors in both in vitro radioligand and isolated tissue assays.
Journal ArticleDOI
A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260
TL;DR: In vivo and in vivo, oral administration of L-365,260 antagonized gastrin-stimulated acid secretion in mice, rats, rats and guinea pigs, and did not antagonize histamine- or carbachol-stimulation in mice.
Journal ArticleDOI
Methods for Drug Discovery: Development of Potent, Selective, Orally Effective Cholecystokinin Antagonists.
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: In this article, 3.3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described.
Journal ArticleDOI
Angiotensin receptor subtypes in rat, rabbit and monkey tissues: relative distribution and species dependency.
TL;DR: The relative affinity of the DuP-753 and WL-19 for the angiotensin receptor subtypes did not vary markedly suggesting that the two angioten receptor sub types in these tissues and species are similar.