Victor Rizzo

TL;DR: It is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases.

TL;DR: Data demonstrate a physiological relevant mechanotransduction event directly in caveolae at the luminal endothelial cell surface to release eNOS from its inhibitory association with caveolin, apparently to allow more complete activation by calmodulin and other possible effectors.

TL;DR: It is reported that chronic exposure to shear stress alters caveolin expression and distribution, increases caveolae density, and leads to enhanced mechanosensitivity to subsequent changes in hemodynamic forces within cultured endothelial cells.

TL;DR: It is shown, for the first time, that not only does mechanotransduction occur at the endothelial cell surface directly exposed to vascular flow in vivo but also increased flowin situ induces rapid tyrosine phosphorylation of luminal endothelialcell surface proteins located primarily in the plasmalemmal invaginations called caveolae.

TL;DR: It is demonstrated how EC can transform fluid shear forces into diverse biomolecular and biomechanical responses, with GPC1 acting as a centralized mechanotransmission agent and SDC1 functioning in decentralized mechanotranmission.