V
Victoria Marini
Researcher at Academy of Sciences of the Czech Republic
Publications - 8
Citations - 323
Victoria Marini is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Cisplatin & DNA. The author has an hindex of 8, co-authored 8 publications receiving 313 citations.
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Journal ArticleDOI
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.
TL;DR: The results support the view that one strategy of how to activate the trans geometry in bifunctional platinum(II) compounds including circumvention of resistance to cisplatin may consist of a chemical modification of the ineffective transplatin that results in an increased stability of its intrastrand cross-links in double-helical DNA and/or in a increased efficiency to form interstrand cross- links.
Journal ArticleDOI
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand: Mechanistic studies on antitumor action
Jana Kasparkova,Olga Novakova,Victoria Marini,Yousef Najajreh,Dan Gibson,J.M. Pérez,Viktor Brabec +6 more
TL;DR: Examination of oligodeoxyribonucleotide duplexes bearing a site-specific cross-link of the transplatin analogue containing the piperidine ligand indicates that in contrast to transplatin, trans-(PtCl2(NH3)(piperidine)) forms stable 1,3-intrastrand cross-links in double-helical DNA that distort DNA and are not readily removed from DNA by nucleotide excision repair system.
Journal ArticleDOI
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].
Victoria Marini,Petros Christofis,Olga Novakova,Jana Kasparkova,Nicholas Farrell,Viktor Brabec +5 more
TL;DR: The results suggest that the multiple DNA lesions available to trans-planaramine complexes may all contribute substantially to their cytotoxicity so that the overall drug cytot toxicity could be the sum of the contributions of each of these adducts.
Journal ArticleDOI
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.
Radim Prokop,Jana Kasparkova,Olga Novakova,Victoria Marini,Ana M. Pizarro,Carmen Navarro-Ranninger,Viktor Brabec +6 more
TL;DR: The results support the view that one strategy to activate trans geometry in bifunctional platinum(II) compounds including circumvention of resistance to cisplatin may consist in a chemical modification of the ineffective transplatin which results in an increased efficiency to form DNA interstrand cross-links.
Journal ArticleDOI
Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin
TL;DR: It is shown that the stability of 1,3-GNG intrastrand CLs of transplatin correlates with the extent of conformational distortion and thermodynamic destabilization induced in double-helical DNA by this adduct.