V
Victoriano Corpas-López
Researcher at University of Granada
Publications - 34
Citations - 467
Victoriano Corpas-López is an academic researcher from University of Granada. The author has contributed to research in topics: Leishmania infantum & Leishmaniasis. The author has an hindex of 11, co-authored 28 publications receiving 289 citations. Previous affiliations of Victoriano Corpas-López include University of Dundee.
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Journal ArticleDOI
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.
Victoriano Corpas-López,Sonia Moniz,Michael G. Thomas,Richard J. Wall,Leah S. Torrie,Dorothea Zander-Dinse,Michele Tinti,Stephen Brand,Laste Stojanovski,Sujatha Manthri,Irene Hallyburton,Fabio Zuccotto,Paul G. Wyatt,Manu De Rycker,David Horn,Michael A. J. Ferguson,Joachim Clos,Kevin D. Read,Alan H. Fairlamb,Ian H. Gilbert,Susan Wyllie +20 more
TL;DR: Oral dosing with compound 2 resulted in a 52% reduction in parasite burden in the authors' mouse model of VL, and N-Myristoyltransferase is now a pharmacologically validated target in Leishmania.
Journal ArticleDOI
(-)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis.
Victoriano Corpas-López,Francisco Morillas-Márquez,M. Concepción Navarro-Moll,Gemma Merino-Espinosa,Victoriano Díaz-Sáez,Joaquina Martín-Sánchez +5 more
TL;DR: In this article, the in vitro and in vivo activity of (−)-α-bisabolol (1) against the etiological agents of visceral leishmaniasis was evaluated.
Journal ArticleDOI
Leishmania infantum in wild rodents: reservoirs or just irrelevant incidental hosts?
H. M. Navea-Pérez,Victoriano Díaz-Sáez,Victoriano Corpas-López,Gemma Merino-Espinosa,Francisco Morillas-Márquez,Joaquina Martín-Sánchez +5 more
TL;DR: The classic epidemiological cycle dog-sandfly-human is turning into a network of animal species that collaborate with the dog in the maintenance of the parasite under natural conditions and probably showing local differences.
Journal ArticleDOI
High rates of Leishmania infantum and Trypanosoma nabiasi infection in wild rabbits (Oryctolagus cuniculus) in sympatric and syntrophic conditions in an endemic canine leishmaniasis area: epidemiological consequences.
Victoriano Díaz-Sáez,Gema Merino-Espinosa,Manuel Morales-Yuste,Victoriano Corpas-López,F. Pratlong,Francisco Morillas-Márquez,Joaquina Martín-Sánchez +6 more
TL;DR: The rabbit seems to meet the most of conditions for being considered a reservoir host of L. infantum, and the presence of the parasite in the skin and blood of these rabbits with no acute manifestation of disease ensures its contact with the vector, which finds in their warrens a suitable biotope to inhabit.
Journal ArticleDOI
The sesquiterpene (−)-α-bisabolol is active against the causative agents of Old World cutaneous leishmaniasis through the induction of mitochondrial-dependent apoptosis
Victoriano Corpas-López,Gemma Merino-Espinosa,Victoriano Díaz-Sáez,Francisco Morillas-Márquez,M. C. Navarro-Moll,Joaquina Martín-Sánchez +5 more
TL;DR: Results suggest that this natural compound induces oxidative stress and mitochondrial-dependent apoptosis on Leishmania without disturbing the plasma membrane.