V
Vijeta Sharma
Researcher at Shiv Nadar University
Publications - 12
Citations - 112
Vijeta Sharma is an academic researcher from Shiv Nadar University. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 7, co-authored 12 publications receiving 86 citations. Previous affiliations of Vijeta Sharma include Jawaharlal Nehru University.
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Journal ArticleDOI
Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity
Dandugudumula Ramu,Swati Garg,R. Ayana,A.K. Keerthana,Vijeta Sharma,C. P. Saini,Subhabrata Sen,Soumya Pati,Shailja Singh,Shailja Singh +9 more
TL;DR: The serendipitous discovery of &bgr;‐carboline‐quinazolinone hybrids with enhanced antileishmanial activity along with the in‐depth structure‐activity relationships and mechanism of action of these analogues is reported.
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Natural Product Inspired Novel Indole based Chiral Scaffold Kills Human Malaria Parasites via Ionic Imbalance Mediated Cell Death.
Poonam Dangi,Ravi Jain,Rajanikanth Mamidala,Vijeta Sharma,Shalini Agarwal,Chandramohan Bathula,M. Thirumalachary,Subhabrata Sen,Shailja Singh,Shailja Singh +9 more
TL;DR: It is shown that ionic imbalance caused by scaffold 7 induces autophagy that leads to onset of apoptosis in the parasite evident by the loss of mitochondrial membrane potential (ΔΨm) and DNA degradation.
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Integrative natural medicine inspired graphene nanovehicle-benzoxazine derivatives as potent therapy for cancer.
Naveen Kumar,Nisha Yadav,Nagarjuna Amarnath,Vijeta Sharma,Swapnil Shukla,Akriti Srivastava,Peeyush Prasad,Anup Kumar,Swati Garg,Shailja Singh,Shailja Singh,Seema Sehrawat,Bimlesh Lochab +12 more
TL;DR: Interestingly, the benzoxazine derivatives of eugenol with GO nanoparticle exhibited enhanced therapeutic potential in cancer cells and significant role of these derivatives on parasite suggesting its multi-pharmacological capability.
Journal ArticleDOI
Benzoxazine derivatives of phytophenols show anti-plasmodial activity via sodium homeostasis disruption.
Vijeta Sharma,Nagarjuna Amarnath,Swapnil Shukla,R. Ayana,Naveen Kumar,Nisha Yadav,Deepika Kannan,Seema Sehrawat,Soumya Pati,Bimlesh Lochab,Shailja Singh,Shailja Singh +11 more
TL;DR: A new class of compounds, 1,3-benzoxazine derivatives of pharmacologically active phytophenols eugenol and isoeugenol synthesised on the principles of green chemistry, as anti-malarials are described, which establish disruption of parasite sodium homeostasis as their mechanism of action.
Journal ArticleDOI
A natural product based DOS library of hybrid systems.
Ganesh N. Prabhu,Shalini Agarwal,Vijeta Sharma,Sanjay M. Madurkar,Parthapratim Munshi,Shailja Singh,Subhabrata Sen +6 more
TL;DR: A systematic comparison of structural intricacy between the library members and a natural product dataset obtained from ZINC(®) revealed comparable complexity.