V
Vilde D. Haakensen
Researcher at University of Oslo
Publications - 20
Citations - 927
Vilde D. Haakensen is an academic researcher from University of Oslo. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 11, co-authored 12 publications receiving 782 citations. Previous affiliations of Vilde D. Haakensen include The Breast Cancer Research Foundation & Oslo University Hospital.
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Journal ArticleDOI
Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
Ivan O. Potapenko,Ivan O. Potapenko,Vilde D. Haakensen,Vilde D. Haakensen,Torben Lüders,Åslaug Helland,Ida Rashida Khan Bukholm,Therese Sørlie,Therese Sørlie,Vessela N. Kristensen,Vessela N. Kristensen,Ole Christian Lingjærde,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale +13 more
TL;DR: Analysis of a set of 419 functionally relevant genes involved in synthesis, degradation and binding of N‐linked and O‐linked glycans, Lewis antigens, glycosaminoglycans and glycosphingolipids indicated that synthesis, degraded and adhesion mediated by glycans may be altered drastically in mammary carcinomas.
Journal ArticleDOI
Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis
Thomas Fleischer,Arnoldo Frigessi,Kevin C. Johnson,Hege Edvardsen,Nizar Touleimat,Jovana Klajic,Jovana Klajic,Margit Riis,Margit Riis,Vilde D. Haakensen,Fredrik Wärnberg,Bjørn Naume,Åslaug Helland,Anne Lise Børresen-Dale,Jörg Tost,Brock C. Christensen,Vessela N. Kristensen,Vessela N. Kristensen +17 more
TL;DR: This work demonstrates that changes in the epigenome occur early in the neoplastic progression, provides evidence for the possible utilization of DNA methylation-based markers of progression in the clinic, and highlights the importance of epigenetic changes in carcinogenesis.
Journal ArticleDOI
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
Vessela N. Kristensen,Charles J. Vaske,Josie Ursini-Siegel,Peter Van Loo,Peter Van Loo,Silje H. Nordgard,Ravi Sachidanandam,Therese Sørlie,Fredrik Wärnberg,Vilde D. Haakensen,Åslaug Helland,Bjørn Naume,Charles M. Perou,David Haussler,Olga G. Troyanskaya,Anne Lise Børresen-Dale +15 more
TL;DR: It is demonstrated that by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, this work can stratify immune signatures that predict patient survival.
Journal ArticleDOI
Association of N-Glycosylation with Breast Carcinoma and Systemic Features Using High-Resolution Quantitative UPLC
Radka Saldova,Akram Asadi Shehni,Vilde D. Haakensen,Israel Steinfeld,Israel Steinfeld,Mark Hilliard,Ilona Kifer,Åslaug Helland,Zohar Yakhini,Zohar Yakhini,Anne Lise Børresen-Dale,Pauline M. Rudd +11 more
TL;DR: The UPLC-based glycan analysis technique described here reveals highly significant differences between healthy women and breast cancer patients, and systemic features show more significant associations with the serum N-glycome than do features of the breast carcinomas.
Journal ArticleDOI
Subtype-specific micro-RNA expression signatures in breast cancer progression.
Vilde D. Haakensen,Vilde D. Haakensen,Vegard Nygaard,Liliana Greger,Miriam Ragle Aure,Miriam Ragle Aure,Bastian Fromm,Ida R. K. Bukholm,Ida R. K. Bukholm,Torben Lüders,Torben Lüders,Suet-Feung Chin,Anna Git,Carlos Caldas,Vessela N. Kristensen,Vessela N. Kristensen,Vessela N. Kristensen,Alvis Brazma,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Eivind Hovig,Eivind Hovig,Åslaug Helland +22 more
TL;DR: The signatures proposed here can form the basis for studies exploring DCIS samples with increased invasive potential and serum biomarkers for in situ and invasive breast cancer.