Vimal K. Balakrishnan

TL;DR: Examination of the toxicity of four PPCPs to midge Chironomus tentans and the freshwater amphipod Hyalella azteca in 10-d waterborne exposures concludes that potential risks exist toward benthic invertebrates for theoxicity of TCS and CBZ and that further investigations of these compounds are required to characterize more completely the risks tobenthic organisms.

TL;DR: Gene network analysis revealed that high concentrations of DY7 in sediment induced cellular stress-related gene transcription and affected genes associated with necrotic cell death, chromosome condensation, and mRNA processing, and transcriptomics generated new hypotheses regarding the mechanisms of toxic action of Dy7.

TL;DR: It is demonstrated that upon release of DY 7 to the aquatic environment, sediment dwelling organisms will metabolize DY7 to generate known (and suspected) human carcinogens, including through a previously unreported in vivo benzidine rearrangement to produce 4-ABP.

TL;DR: It is suggested that consumption of invertebrate food items could provide an additional source of exposure to estrogenic substances in vertebrate predators.

TL;DR: The similarities of the structures and larval fish responses for the two azo and two anthracenedione dyes in this study support the use of read-across data for risk assessment of these classes of compounds.