Vincent A. Ziboh

TL;DR: In this investigation, effects of naturally occurring flavonoids on epidermal cyclooxygenase/lip oxygengenase were studied using five selected derivatives: flavanone, apigenin, quercetin (flavonol), amentoflavone and ginkgetin (biflavone) because eicosanoids generated in the epidermis are believed to be involved in various biological activities of the skin.

TL;DR: In the skin epidermis, the metabolism of polyunsaturated fatty acids (PUFAs) is highly active as discussed by the authors, and it is shown that supplementing diets with appropriate purified vegetable oils, fish oil or both may generate local cutaneous antiinflammatory and antiproliferative metabolites which could serve as less toxic in vivo monotherapies or as adjuncts to standard therapeutic regimens for the management of inflammatory skin disorders.

TL;DR: This research sought to identify inexpensive, safe, vegetable oils available in developing countries that improved epidermal barrier function and saw adverse ultrastructural changes seen under transmission electron microscopy in keratin intermediate filament, mitochondrial, nuclear, and nuclear envelope structure following a single application of mustard oil.

TL;DR: In this paper, Linoleic acid was used to correct the defect in barrier function of essential fatty acid deficiency in EFA-deficient rodents, which can either reflect a prostaglandin-mediated return toward normal epidermal differentiation, or, instead, a direct effect of linoleic acids.

TL;DR: The need for further investigations into the role of dietary n3 fatty acids, particularly the possibility of pentaenoic acid as a potential protective agent and/or therapeutic adjunct for the clinical management of psoriasis, is underscored.