Journal ArticleDOI
Effects of Dietary Supplementation of Fish Oil on Neutrophil and Epidermal Fatty Acids: Modulation of Clinical Course of Psoriatic Subjects
Vincent A. Ziboh,Kenneth A. Cohen,Charles N. Ellis,Craig C. Miller,Ted A. Hamilton,Knud Kragballe,Constance R. Hydrick,John J. Voorhees +7 more
Reads0
Chats0
TLDR
The need for further investigations into the role of dietary n3 fatty acids, particularly the possibility of pentaenoic acid as a potential protective agent and/or therapeutic adjunct for the clinical management of psoriasis, is underscored.Abstract:
† Findings from an eight-week fish oil-supplemented diet given to 13 psoriatic patients demonstrated that eicosapentaenoic acid (20:5,n3 [EPA]) and docosahexaenoic acid (22:6,n3 [DCHA]) are rapidly incorporated into the sera, neutrophils, and epidermis of participating patients, and that the incorporation of EPA and DCHA into epidermal lipids increased with weeks of supplementation with minimal alteration of arachidonic acid (AA) in the epidermal lipids. Global clinical evaluation showed that eight patients demonstrated mild to moderate improvement in their psoriatic lesions. Improved clinical response correlated with high EPA/DCHA ratios attained in epidermal tissue specimens. These findings underscore the need for further investigations into the role of dietary n3 fatty acids, particularly the possibility of pentaenoic acid as a potential protective agent and/or therapeutic adjunct for the clinical management of psoriasis. ( Arch Dermatol 1986;122:1277-1282)read more
Citations
More filters
Journal ArticleDOI
Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan.
TL;DR: It is suggested that increased dietary intake of animal protein and n-6 polyunsaturated fatty acids with less n-3 polyuns saturated fatty acids may contribute to the development of Crohn disease.
Journal ArticleDOI
A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis
TL;DR: In this paper, patients with stable chronic psoriasis completed a trial in which they were randomly allocated to receive either 10 fish-oil capsules ('MaxEPA') or 10 placebo capsules (olive oil) daily.
Journal ArticleDOI
Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions.
TL;DR: Several studies have reported that dietary fish oil supplementation alters cytokine production and other functional activities of peripheral blood mononuclear cells (PBMC) but few have related the functional changes to alterations in PBMC fatty acid composition.
Journal ArticleDOI
Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites
TL;DR: In the skin epidermis, the metabolism of polyunsaturated fatty acids (PUFAs) is highly active as discussed by the authors, and it is shown that supplementing diets with appropriate purified vegetable oils, fish oil or both may generate local cutaneous antiinflammatory and antiproliferative metabolites which could serve as less toxic in vivo monotherapies or as adjuncts to standard therapeutic regimens for the management of inflammatory skin disorders.
Book ChapterDOI
The biochemistry and function of stratum corneum lipids.
Nanna Y. Schürer,Peter M. Elias +1 more
TL;DR: This chapter discusses the biochemistry and function of stratum corneum lipids and suggests that a major component of the stratum Corneum is a ceramide, consisting of 30 to 34-carbon chain length, N-acyl, ω-hydroxyacids covalently bound to the cornified envelope.
References
More filters
Journal ArticleDOI
Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis
TL;DR: Unlike arachidonic acid, eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.X.A.P.), probably because of the formation of thromboxane A3 (T.G.I3) which does not have platelet aggregating properties.
Journal ArticleDOI
The composition of food consumed by Greenland Eskimos.
H O Bang,Jørn Dyerberg,N Hjøorne +2 more
TL;DR: Food specimens have been collected from Greenland Eskimo hunters and their wives, in all seven persons, on seven consecutive days, and their food was found to contain more protein and less carbohydrates than average Danish food and an almost equal amount of fat.
Journal ArticleDOI
Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties
TL;DR: It is possible that the triene prostaglandins are potential antithrombotic agents because their precursor fatty acids, as well as their transformation products, PGH, thromboxane A(3), and PGI, are capable of interfering with aggregation of platelets in platelet-rich plasma.
Journal ArticleDOI
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis
TL;DR: The cardiovascular protective effects ascribed to dietary intake of fish lipid by certain populations may be due in part to the biological action of DCHA, including the inhibition of prostaglandin biosynthesis.
Journal ArticleDOI
Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.
TL;DR: The potency of LTB5 relative to LTB4 was approximately 1:8 as a chemotactic agent and about 1:20 as an aggregating agent and only (5S,12S)-6-trans-8-cis-LTB4 had even minimal aggregating activity.