Vincent R. Bonagura

TL;DR: It is shown that the affinity of FcRn for IgG is reduced about 2 orders of magnitude as the pH is raised from 6.0 to 7.0, and it is demonstrated that IgG histidines located at the junction between the CH2 and CH3 domains contribute to the pH-dependent affinity transition.

TL;DR: The crystal structure of the Fab fragment of a patient-derived IgM rheumatoid factor complexed with human lgG4 Fc, at 3.2 Å resolution, is reported, which is the first structure of an autoantibody–autoantigen complex.

TL;DR: Parents of children with food allergy are more sensitive to the societal cost of their children’s food allergies than many people give them credit for, whereas schools mostly identified major needs for staff retraining and liability coverage if the system were to be introduced.

TL;DR: A complex defect in immune responsiveness to human papillomavirus‐6 and ‐11 is identified and this defect can be a cause for concern in patients with recurrent respiratory papilomatosis.

TL;DR: It is predicted that immunization with live attenuated varicella vaccine is unlikely to be deleterious to HIV-infected children, but if they are immunized when they still have relatively normal levels of CD4+ lymphocytes, they may have a lower rate of reactivation of VZV than if they were allowed to develop natural varICElla when theirCD4+ cell counts have fallen to low levels as a result of progressive HIV infection.