Vincenzo C. Russo

TL;DR: In vitro studies have demonstrated that the IGF system promotes differentiation and proliferation and sustains survival, preventing apoptosis of neuronal and brain derived cells and studies of transgenic mice overexpressing components of the IGFsystem or mice with disruptions of the same genes have clearly shown thatThe IGF system plays a key role in vivo.

TL;DR: The findings suggest that the IGF-1 produced by microglia after injury is transferred to perineuronal reactive astrocytes expressing IGFBP-2, which might represent a key mechanism that restricts neuronal cell loss following HI brain injury.

TL;DR: It was found that high levels of IGF‐1 or insulin promoted the maturation and affected the neurotransmitter phenotype of the neurons generated, and it appears that endogenous IGF‐ 1 may be a major regulator of stem cell differentiation into neurons.

TL;DR: It is demonstrated, for the first time, that leptin stimulates, in a time- and dose-dependent manner, neuroblastoma cell proliferation and that the underlying mechanisms involve suppression of apoptosis via the Janus kinase-STAT, phosphatidylinositol-3 kinase, and MAPK pathways that culminate altogether in the down-regulation of the apoptotic factors caspase-10 and TNF-related apoptosis-inducing ligand.

TL;DR: In this paper, the effects of mutations of the heparin binding domain (HBD) or the arginine-glycine-aspartic acid (RGD) integrin binding motif on extracellular matrix (ECM) binding were investigated.