V
Violetta Cecchetti
Researcher at University of Perugia
Publications - 151
Citations - 3491
Violetta Cecchetti is an academic researcher from University of Perugia. The author has contributed to research in topics: Benzothiazine & Efflux. The author has an hindex of 32, co-authored 146 publications receiving 3004 citations. Previous affiliations of Violetta Cecchetti include Rega Institute for Medical Research & University of Düsseldorf.
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Journal ArticleDOI
A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.
Serena Massari,Dirk Daelemans,Maria Letizia Barreca,Anna Knezevich,Stefano Sabatini,Violetta Cecchetti,Alessandro Marcello,Christophe Pannecouque,Oriana Tabarrini +8 more
TL;DR: The naphthyridone 3 (HM13N), described in the present study, is a promising anti-HIV agent due to its ability to inhibit the HIV-1 Tat-mediated transcription and the potent antiviral activity observed in acutely, chronically, and latently infected cells.
Journal ArticleDOI
Effects of Novel 6-Desfluoroquinolones and Classic Quinolones on Pentylenetetrazole-Induced Seizures in Mice
TL;DR: The relationship between the chemical structure and the proconvulsant activity of 6-desfluoroquinolone derivatives was studied and it was observed that, in terms of toxicity to the central nervous system (CNS), the C-6 substituent also appears to play an important role.
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6-Aminoquinolones as new potential anti-HIV agents.
Violetta Cecchetti,Cristina Parolin,Stefano Moro,Teresa Pecere,Enrica Filipponi,Arianna Calistri,Oriana Tabarrini,Barbara Gatto,Manlio Palumbo,Arnaldo Fravolini,Giorgio Palu +10 more
TL;DR: Active quinolone derivatives very efficiently interact with TAR RNA, which suggests a nucleic acid-targeted mechanism of action in HIV-1 replication.
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Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.
Stefano Sabatini,Francesca Gosetto,Giuseppe Manfroni,Oriana Tabarrini,Glenn W. Kaatz,Diixa Patel,Violetta Cecchetti +6 more
TL;DR: These compounds, in combination with ciprofloxacin, were able to completely restore its antibacterial activity against both S. aureus SA-K2378 and SA-1199B, norA-overexpressing strains.
Journal ArticleDOI
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
Violetta Cecchetti,Arnaldo Fravolini,Renata Fringuelli,Giuseppe Mascellani,Piergiuseppe Pagella,Maurizio Palmioli,Giorgio Segre,Patrizia Terni +7 more
TL;DR: The compound 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido (MF-934) has been found to possess, together with the antibacterial activity, a weak acute toxicity and interesting pharmacokinetic characteristics in several animal species.