S
Stefano Sabatini
Researcher at University of Perugia
Publications - 98
Citations - 2795
Stefano Sabatini is an academic researcher from University of Perugia. The author has contributed to research in topics: Efflux & Medicine. The author has an hindex of 28, co-authored 88 publications receiving 2007 citations. Previous affiliations of Stefano Sabatini include Rega Institute for Medical Research.
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Towards the sustainable discovery and development of new antibiotics
Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammann,Ludovic Halby,Paola B. Arimondo,Philippe Glaser,Bertrand Aigle,Helge B. Bode,Helge B. Bode,Rui Moreira,Yanyan Li,Andriy Luzhetskyy,Marnix H. Medema,Jean-Luc Pernodet,Marc Stadler,José R. Tormo,Olga Genilloud,Andrew W. Truman,Kira J. Weissman,Eriko Takano,Stefano Sabatini,Evi Stegmann,Heike Brötz-Oesterhelt,Wolfgang Wohlleben,Myriam Seemann,Martin Empting,Anna K. H. Hirsch,Brigitta Loretz,Claus-Michael Lehr,Alexander Titz,Jennifer Herrmann,Timo Jaeger,Silke Alt,Thomas Hesterkamp,Mathias Winterhalter,Andrea Schiefer,Kenneth Pfarr,Achim Hoerauf,Heather Graz,Michael Graz,Mika Lindvall,Savithri Ramurthy,Anders Karlén,Maarten van Dongen,Hrvoje Petković,Andreas Keller,Frédéric Peyrane,Stefano Donadio,Laurent Fraisse,Laura J. V. Piddock,Ian H. Gilbert,Heinz E. Moser,Rolf Müller +54 more
TL;DR: In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.
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A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.
Serena Massari,Dirk Daelemans,Maria Letizia Barreca,Anna Knezevich,Stefano Sabatini,Violetta Cecchetti,Alessandro Marcello,Christophe Pannecouque,Oriana Tabarrini +8 more
TL;DR: The naphthyridone 3 (HM13N), described in the present study, is a promising anti-HIV agent due to its ability to inhibit the HIV-1 Tat-mediated transcription and the potent antiviral activity observed in acutely, chronically, and latently infected cells.
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From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump.
TL;DR: A series of 1,4-benzothiazine derivatives were designed and synthesized as a minimized structural template of phenothiazines MDR efflux pump inhibitors (EPIs) in an effort to identify more potent S. aureus NorA EPIs.
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Impact of conventional/non-conventional extraction methods on the untargeted phenolic profile of Moringa oleifera leaves.
Gabriele Rocchetti,Francesca Blasi,Domenico Montesano,Silvia Ghisoni,Maria Carla Marcotullio,Stefano Sabatini,Lina Cossignani,Luigi Lucini +7 more
TL;DR: It is demonstrated that each extraction method promoted the recovery of specific phenolic subclasses with different efficiencies, mainly affected by the different extraction technologies.
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Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.
Stefano Sabatini,Francesca Gosetto,Giuseppe Manfroni,Oriana Tabarrini,Glenn W. Kaatz,Diixa Patel,Violetta Cecchetti +6 more
TL;DR: These compounds, in combination with ciprofloxacin, were able to completely restore its antibacterial activity against both S. aureus SA-K2378 and SA-1199B, norA-overexpressing strains.