V
Vishal Ranjan
Researcher at Central Drug Research Institute
Publications - 5
Citations - 185
Vishal Ranjan is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: MCF-7 & Apoptosis. The author has an hindex of 5, co-authored 5 publications receiving 174 citations. Previous affiliations of Vishal Ranjan include Allahabad University & Council of Scientific and Industrial Research.
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Journal ArticleDOI
Centchroman induces G0/G1 arrest and caspase-dependent apoptosis involving mitochondrial membrane depolarization in MCF-7 and MDA MB-231 human breast cancer cells.
TL;DR: Results demonstrate that CC induces caspase-dependent apoptosis in MCF-7 and MDA MB-231 cells irrespective of ER status similar to TAM in terms of anti-neoplastic activity.
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Caspase Mediated Enhanced Apoptotic Action of Cyclophosphamide- and Resveratrol-Treated MCF-7 Cells
Neetu Singh,Manisha Nigam,Vishal Ranjan,Ramesh C. Sharma,Anil K. Balapure,Srikanta Kumar Rath +5 more
TL;DR: It is found that RES significantly enhances the caspase-mediated cytotoxic activity of CPA on MCF-7 cells in vitro, suggesting the possibility of a new combination chemotherapeutic regimen leading to improvements in the treatment of breast cancer.
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Resveratrol as an adjunct therapy in cyclophosphamide‐treated MCF‐7 cells and breast tumor explants
Neetu Singh,Manisha Nigam,Vishal Ranjan,Vishal Ranjan,Deeba Zaidi,Vivek Garg,Sharad Sharma,Rashmi Chaturvedi,Rishi Shankar,Sadan Kumar,Ramesh C. Sharma,Kalyan Mitra,Anil K. Balapure,Srikanta Kumar Rath +13 more
TL;DR: The molecular basis of 5’mM CPA and 50’μM RES as a combination on cell‐cycle progression, apoptosis and oxidative stress in MCF‐7 breast cancer cells is explored and co‐treatment superiority in histologically validated ER positive breast cancer explants suggests that this combination may be a worthy future clinical anti‐neoplastic regimen.
Journal ArticleDOI
Centchroman mediated apoptosis involves cross-talk between extrinsic/intrinsic pathways and oxidative regulation.
Manisha Nigam,Neetu Singh,Vishal Ranjan,Vishal Ranjan,Deeba Zaidi,Deeba Zaidi,Ramesh C. Sharma,Deepti Nigam,Dwijendra K. Gupta,Shanthy Sundaram,Anil Kumar Balapure +10 more
TL;DR: Results confirm that the antineoplasticity of CC in MCF-7 and MDA MB-231 cells involves the extrinsic and intrinsic pathways of apoptosis along with oxidative stress.
Journal ArticleDOI
Insulin catalyzes the curcumin-induced wound healing: an in vitro model for gingival repair.
Neetu Singh,Vishal Ranjan,Deeba Zaidi,Hari Shyam,Aparna Singh,Divya Lodha,Ramesh C. Sharma,Umesh Pratap Verma,Jaya Dixit,Anil K. Balapure +9 more
TL;DR: The in vitro model for gingival wound healing establishes that insulin significantly enhanced wound filling faster than CUR-treated hGF cells over 48 h, which reinforces the pivotal role of insulin in supporting C UR-mediated wound repair.