Journal ArticleDOI
Centchroman induces G0/G1 arrest and caspase-dependent apoptosis involving mitochondrial membrane depolarization in MCF-7 and MDA MB-231 human breast cancer cells.
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Results demonstrate that CC induces caspase-dependent apoptosis in MCF-7 and MDA MB-231 cells irrespective of ER status similar to TAM in terms of anti-neoplastic activity.About:
This article is published in Life Sciences.The article was published on 2008-03-12. It has received 66 citations till now. The article focuses on the topics: Apoptosis & Estrogen receptor.read more
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Nuclear Receptors and Their Selective Pharmacologic Modulators
Thomas P. Burris,Laura A. Solt,Yongjun Wang,Christine Crumbley,Subhashis Banerjee,Kristine Griffett,Thomas Lundasen,Travis S. Hughes,Douglas J. Kojetin +8 more
TL;DR: The development and pharmacology of a range of selective nuclear receptor modulators are reviewed, where ligands display agonist/partial agonist-binding domain of nuclear receptors function in a tissue or gene selective manner.
Journal ArticleDOI
Activation of TGF-β Pathway by Areca Nut Constituents: A Possible Cause of Oral Submucous Fibrosis
TL;DR: A major causative role for TGF-β is suggested that is induced by areca nut in OSF progression, suggesting epithelial cells could be the source of T GF-β in promoting OSF.
Journal ArticleDOI
Programmed Cell Death, from a Cancer Perspective: An Overview
Abhay Prakash Mishra,Bahare Salehi,Mehdi Sharifi-Rad,Raffaele Pezzani,Farzad Kobarfard,Javad Sharifi-Rad,Manisha Nigam +6 more
TL;DR: A brief outline of PCD types as well as their role in cancer therapeutics is discussed, since irregularities in the cell death process are frequently found in various cancers, key proteins governing cell death type could be used as therapeutic targets for a wide range of cancer.
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Apoptosis induction in human breast cancer (MCF-7) cells by a novel venom l -amino acid oxidase (Rusvinoxidase) is independent of its enzymatic activity and is accompanied by caspase-7 activation and reactive oxygen species production
Ashis K. Mukherjee,Ashis K. Mukherjee,Anthony J. Saviola,Anthony J. Saviola,P.D. Burns,Stephen P. Mackessy +5 more
TL;DR: Rusvinoxidase at a dose of 4 mg/kg was non-toxic in mice, indicating that it may be useful as a model for the development of peptide-based anticancer drugs.
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Equol enhances tamoxifen’s anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells
TL;DR: Equol may be used therapeutically in combination treatments and clinical studies to enhance tamoxifen’s effect by providing additional protection against estrogen-responsive breast cancers.
References
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A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
TL;DR: The present study arose from the observation that a more intense colour was sometimes produced if, instead of being heated at 1000 for 10 min., the reaction mixture was allowed to stand overnight at room temperature.
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Cell Death: Critical Control Points
TL;DR: The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
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Molecular characterization of mitochondrial apoptosis-inducing factor
Santos A. Susin,Hans K. Lorenzo,Naoufal Zamzami,Isabel Marzo,Bryan E. Snow,Joan Mangion,Etienne Jacotot,Paola Costantini,Markus Loeffler,Nathanael Larochette,David R. Goodlett,Ruedi Aebersold,David P. Siderovski,Josef M. Penninger,Guido Kroemer +14 more
TL;DR: The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.
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Cell-cycle checkpoints and cancer
Michael B. Kastan,Jiri Bartek +1 more
TL;DR: All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation, and how cells respond to DNA damage are critical determinants of whether that individual will develop cancer.
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The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
Andrew K. Shiau,Danielle Barstad,Paula M. Loria,Lin Cheng,Peter J. Kushner,David A. Agard,Geoffrey L. Greene +6 more
TL;DR: Crystal structures of the human estrogen receptor alpha (hER alpha) ligand-binding domain (LBD) and the OHT-LBD complex reveal the two distinct mechanisms by which structural features of OHT promote this "autoinhibitory" helix 12 conformation.