V
Vito Alessandro Lasorsa
Researcher at University of Naples Federico II
Publications - 41
Citations - 582
Vito Alessandro Lasorsa is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 27 publications receiving 293 citations.
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Journal ArticleDOI
Discovery of epi-Enprioline as a Novel Drug for the Treatment of Vincristine Resistant Neuroblastoma.
Wondossen Sime,Mohamed Jemaà,Yasmin Abassi,Vito Alessandro Lasorsa,Julie Bonne Køhler,Karin Hansson,Daniel Bexell,Martin Michaelis,Jindrich Cinatl,Daniel Strand,Mario Capasso,Ramin Massoumi +11 more
TL;DR: The data suggest that epi-enprioline can be considered as a lead compound for the treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant Neuroblastoma.
Journal ArticleDOI
FGFR1 is a potential therapeutic target in neuroblastoma
Flora Cimmino,Anna Montella,Matilde Tirelli,Marianna Avitabile,Vito Alessandro Lasorsa,Feliciano Visconte,Sueva Cantalupo,Teresa Maiorino,Biagio De Angelis,Martina Morini,Aurora Castellano,Franco Locatelli,Mario Capasso,Achille Iolascon +13 more
TL;DR: In this paper , the authors investigated the role of FGFR1 and the implication of N546K mutation in therapy-resistance in NB cells, and they found that FGFR 1 expression correlated with low relapse-free survival in two independent NB gene expression datasets.
Journal ArticleDOI
Methylome Analysis in Nonfunctioning and GH-Secreting Pituitary Adenomas
G. Giuffrida,Valeria D'Argenio,Francesco Ferraù,Vito Alessandro Lasorsa,Francesca Polito,Federica Aliquò,Marta Ragonese,Oana Ruxandra Cotta,Y. Alessi,Rosaria Oteri,Federica Di Maggio,Alessio Asmundo,Petronilla Daniela Romeo,Federica Spagnolo,Lucio Pastore,Filippo Flavio Angileri,Mario Capasso,Salvatore Cannavò,M'hammed Aguennouz +18 more
TL;DR: A significant prevalence of hypermethylation in NFPAs vs. GH-omas is confirmed and three hypermethylated genes involved in tumorigenesis processes and potentially influencing pituitary tumor pathophysiology are found.
Journal ArticleDOI
Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1.
Antonella Cardinale,Antonella Cardinale,Sueva Cantalupo,Vito Alessandro Lasorsa,Annalaura Montella,Flora Cimmino,Mariangela Succoio,Michiel Vermeulen,Marijke P. Baltissen,Matteo Esposito,Marianna Avitabile,Daniela Formicola,Alessandro Testori,Ferdinando Bonfiglio,Paola Ghiorzo,Massimiliano Scalvenzi,Fabrizio Ayala,Nicola Zambrano,Mark M. Iles,Mai Xu,Matthew Law,Matthew Law,Kevin M. Brown,Achille Iolascon,Mario Capasso +24 more
TL;DR: The 10q24.33 locus is known to be associated with susceptibility to cutaneous malignant melanoma (CMM), but the mechanisms underlying this association have not extensively investigated.
Journal ArticleDOI
Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways
Marianna Avitabile,Ferdinando Bonfiglio,Vincenzo Aievola,Sueva Cantalupo,Teresa Maiorino,Vito Alessandro Lasorsa,Cinzia Domenicotti,Barbara Marengo,Heger Zbyněk,Adam Vojtech,Achille Iolascon,Mario Capasso +11 more
TL;DR: In this paper , the authors performed single cell RNA sequencing (scRNAseq) of etoposide and cisplatin resistant NB and their parental cells and found that drug resistance can affect NB cell identities; highlighting the bi-directional ability of adrenergic-tomesenchymal transition of NB cells.