Vittoria Donofrio

TL;DR: It is shown that miR-199b-5p expression correlates with metastasis spread, identifying a new molecular marker for a poor-risk class in patients with MB, and that in a xenograft model, MB tumor burden can be reduced, indicating the use of miR199b -5p as an adjuvant therapy after surgery, in combination with radiation and chemotherapy, for the improvement of anti-cancer MB therapies and patient quality of life.

TL;DR: In this paper, the authors evaluated the prognostic value of histological grading and expression of p53 and YKL-40 in a series of 43 pediatric high-grade gliomas (21 anaplastic astrocytoma and 22 glioblastoma WHO grade IV).

TL;DR: Atypical Spitz tumors require complete excision and careful follow-up while the data do not support any clinical benefit for the sentinel lymph node biopsy procedure and completion lymphadenectomy.

TL;DR: Immunohistochemistry using both p65/RELA and L1CAM antibodies is valuable for ST-EP-RELA diagnosis: the negativity with both antibodies consistently predicts the absence of RELA fusions, whereas verification of fusion transcripts by molecular analyses is warranted only in single-positive or double-positive staining cases.

TL;DR: To evaluate the prognostic factors in a series of children affected by pleuropulmonary blastoma (PPB), a large number of children were diagnosed with atypical central giant cell granuloma and their prognosis was poor.