Sarah Fattet

TL;DR: It is shown that miR-199b-5p expression correlates with metastasis spread, identifying a new molecular marker for a poor-risk class in patients with MB, and that in a xenograft model, MB tumor burden can be reduced, indicating the use of miR199b -5p as an adjuvant therapy after surgery, in combination with radiation and chemotherapy, for the improvement of anti-cancer MB therapies and patient quality of life.

TL;DR: Data confirm and extend previous observations that CTNNB1‐mutated tumours represent a distinct molecular subgroup of medulloblastomas with favourable outcome, indicating that therapy de‐escalation should be considered.

TL;DR: Together, the data reveal a novel function of p110α in medulloblastoma growth and survival, which was selective, because RNA interference targeting of p 110β or p110δ did not result in a comparable impairment of DAOY cell survival.

TL;DR: Intravenous pamidronate is a safe and effective treatment for severe cancer-related hypercalcemia in children andSerum calcium levels must be monitored for a fortnight after administration of pamodronate due to the risk of hypocalcemia.

TL;DR: The data show that the p110γ phosphoinositide 3-kinase isoform is a novel target for combinatorial therapies in medulloblastoma.