V
Viveka Nand Yadav
Researcher at University of Michigan
Publications - 33
Citations - 709
Viveka Nand Yadav is an academic researcher from University of Michigan. The author has contributed to research in topics: Glioma & Complement control protein. The author has an hindex of 11, co-authored 29 publications receiving 500 citations. Previous affiliations of Viveka Nand Yadav include Savitribai Phule Pune University.
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Journal ArticleDOI
Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy
Gregory J. Baker,Viveka Nand Yadav,Sebastien Motsch,Carl Koschmann,Anda Alexandra Calinescu,Yohei Mineharu,Sandra Camelo-Piragua,Daniel A. Orringer,Serguei Bannykh,W. S. Nichols,Ana C. deCarvalho,Tom Mikkelsen,Maria G. Castro,Pedro R. Lowenstein +13 more
TL;DR: Agent-based computational modeling recapitulated biological perivascular glioma growth without the need for neoangiogenesis, providing compelling experimental evidence in support of the recently described failure of clinically used antiangiogenics to extend the overall survival of human GBM patients.
Journal ArticleDOI
Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas.
Chan Chung,Stefan Sweha,Drew Pratt,Benita Tamrazi,Pooja Panwalkar,Adam Banda,Jill Bayliss,Debra Hawes,Fusheng Yang,Ho-Joon Lee,Mengrou Shan,Marcin Cieslik,Tingting Qin,Christian K. Werner,Daniel R. Wahl,Costas A. Lyssiotis,Zhiguo Bian,J. Brad Shotwell,Viveka Nand Yadav,Carl Koschmann,Arul M. Chinnaiyan,Stefan Bluml,Alexander R. Judkins,Sriram Venneti +23 more
TL;DR: Overall, it is demonstrated that H3.3K27M and mIDH1 hijack a conserved and critical metabolic pathway in opposing ways to maintain their preferred epigenetic state, and interruption of this metabolic/epigenetic pathway showed potent efficacy in preclinical models, suggesting key therapeutic targets for much needed treatments.
Journal ArticleDOI
CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study
Viveka Nand Yadav,Daniel Zamler,Gregory J. Baker,Padma Kadiyala,Anat Erdreich-Epstein,Ana C. deCarvalho,Tom Mikkelsen,Maria G. Castro,Pedro R. Lowenstein +8 more
TL;DR: The data suggest that CXCR4 signaling is critical for perivascular invasion of GBM cells and targeting this receptor makes tumors less invasive and more sensitive to radiation therapy.
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Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity.
Gregory J. Baker,Peter Chockley,Viveka Nand Yadav,Robert Doherty,Michael Ritt,Sivaraj Sivaramakrishnan,Maria G. Castro,Pedro R. Lowenstein +7 more
TL;DR: It is shown that malignant glioma cells suppress NK immune surveillance by overexpressing the β-galactoside-binding lectin galectin-1, suggesting that galectIn-1 suppression in humanglioma could improve patient survival by restoring NK immune Surveillance that can eradicate gli cancer cells.
Journal ArticleDOI
Survival and proliferation of neural progenitor derived glioblastomas under hypoxic stress is controlled by a CXCL12/CXCR4 autocrine positive feedback mechanism.
Anda Alexandra Calinescu,Viveka Nand Yadav,Erica Carballo,Padma Kadiyala,Dustin Tran,Daniel Zamler,Robert Doherty,Maithreyi Srikanth,Pedro R. Lowenstein,Maria G. Castro +9 more
TL;DR: This study demonstrates that the CXCL12/CXCR4 axis operates in glioblastoma cells under hypoxic stress via an autocrine-positive feedback mechanism, which promotes survival and cell-cycle progression.