M
Marcin Cieslik
Researcher at University of Michigan
Publications - 71
Citations - 7732
Marcin Cieslik is an academic researcher from University of Michigan. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 20, co-authored 42 publications receiving 3857 citations. Previous affiliations of Marcin Cieslik include Howard Hughes Medical Institute.
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Journal ArticleDOI
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
Weimin Wang,Michael D. Green,Jae Eun Choi,Miguel Gijón,Paul D. Kennedy,Jeffrey K. Johnson,Peng Liao,Xueting Lang,Ilona Kryczek,Amanda Sell,Houjun Xia,Jiajia Zhou,Gaopeng Li,Jing Li,Wei Li,Shuang Wei,Linda Vatan,Hongjuan Zhang,Wojciech Szeliga,Wei Gu,Rebecca Liu,Theodore S. Lawrence,Candice Lamb,Yuri Tanno,Marcin Cieslik,Everett Stone,George Georgiou,Timothy A. Chan,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Weiping Zou +30 more
TL;DR: Investigation of human transcriptomes before and during nivolumab therapy revealed that clinical benefits correlate with reduced expression of SLC3A2 and increased IFNγ and CD8 and targeting this pathway in combination with checkpoint blockade is a potential therapeutic approach.
Journal ArticleDOI
The Landscape of Circular RNA in Cancer.
Josh N. Vo,Marcin Cieslik,Yajia Zhang,Sudhanshu Shukla,Sudhanshu Shukla,Lanbo Xiao,Yuping Zhang,Yi-Mi Wu,Saravana M. Dhanasekaran,Carl G. Engelke,Xuhong Cao,Dan R. Robinson,Alexey I. Nesvizhskii,Arul M. Chinnaiyan +13 more
TL;DR: An exome capture RNA sequencing protocol is used to detect and characterize circRNAs across >2,000 cancer samples and built the most comprehensive catalog of circRNA species to date, MiOncoCirc, the first database to be composed primarily of circ RNAs directly detected in tumor tissues.
Journal ArticleDOI
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
Irfan A. Asangani,Vijaya L. Dommeti,Xiaoju Wang,Rohit Malik,Marcin Cieslik,Rendong Yang,June Escara-Wilke,Kari Wilder-Romans,Sudheer Dhanireddy,Carl G. Engelke,Mathew K. Iyer,Xiaojun Jing,Yi-Mi Wu,Xuhong Cao,Zhaohui S. Qin,Shaomeng Wang,Felix Y. Feng,Arul M. Chinnaiyan +17 more
TL;DR: It is shown that AR-signalling-competent human CRPC cell lines are preferentially sensitive to bromodomain and extraterminal (BET) inhibition, which provides a novel epigenetic approach for the concerted blockade of oncogenic drivers in advanced prostate cancer.
Journal ArticleDOI
Genomic correlates of clinical outcome in advanced prostate cancer.
Wassim Abida,Joanna Cyrta,Joanna Cyrta,Glenn Heller,Davide Prandi,Joshua Armenia,Ilsa Coleman,Marcin Cieslik,Matteo Benelli,Dan R. Robinson,Eliezer M. Van Allen,Eliezer M. Van Allen,Andrea Sboner,Tarcisio Fedrizzi,Juan Miguel Mosquera,Brian D. Robinson,Navonil De Sarkar,Lakshmi P. Kunju,Scott A. Tomlins,Yi-Mi Wu,Daniel Nava Rodrigues,Massimo Loda,Massimo Loda,Anuradha Gopalan,Victor E. Reuter,Colin C. Pritchard,Joaquin Mateo,Diletta Bianchini,Susana Miranda,Suzanne Carreira,Pasquale Rescigno,Julie Filipenko,Jacob Vinson,Robert B. Montgomery,Himisha Beltran,Himisha Beltran,Elisabeth I. Heath,Howard I. Scher,Philip W. Kantoff,Mary-Ellen Taplin,Nikolaus Schultz,J. De-Bono,Francesca Demichelis,Peter S. Nelson,Mark A. Rubin,Mark A. Rubin,Arul M. Chinnaiyan,Charles L. Sawyers +47 more
TL;DR: This large analysis integrating mCRPC genomics with histology and clinical outcomes identifies RB1 genomic alteration as a potent predictor of poor outcome, and is a community resource for further interrogation of clinical and molecular associations.
Journal ArticleDOI
Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11
Xueting Lang,Michael D. Green,Weimin Wang,Jiali Yu,Jae Eun Choi,Long Jiang,Peng Liao,Jiajia Zhou,Qiang Zhang,Ania Dow,Anjali L. Saripalli,Ilona Kryczek,Shuang Wei,Wojciech Szeliga,Linda Vatan,Everett Stone,George Georgiou,Marcin Cieslik,Marcin Cieslik,Daniel R. Wahl,Meredith A. Morgan,Arul M. Chinnaiyan,Theodore S. Lawrence,Weiping Zou +23 more
TL;DR: It is demonstrated that radiotherapy induces tumor cell ferroptosis, an unappreciated mechanism and focus for the development of effective combinatorial cancer therapy.