Viviana Gradinaru

TL;DR: CAP-Mac as discussed by the authors is an engineered variant identified by screening in adult marmosets and newborn macaques with improved efficiency in the brain of multiple NHP species: marmoset, rhesus macaque, and green monkey.

TL;DR: In this paper, the authors describe a method for using light-sensitive proteins to enable minimally-invasive neuronal circuit interrogation in living organism, and treat neuronal and ocular disorders.

TL;DR: In this paper, the authors present methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of the urinary bladder, external urethra, and the male and female genitalia.

TL;DR: In this article, a bone tissue clearing method with enhanced optical access is described, which includes continuous convective flow during the clearing process, amino alcohol to minimize tissue autofluorescence, and an imaging procedure that minimizes refractive index variations in light-sheet microscopy.

TL;DR: This research presents a novel probabilistic approach to estimating the response of the immune system to EMTs, which has the potential to improve the odds of successfully diagnosing and treating central nervous system disorders.