V
Viviana Gradinaru
Researcher at California Institute of Technology
Publications - 160
Citations - 21884
Viviana Gradinaru is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 49, co-authored 137 publications receiving 16560 citations. Previous affiliations of Viviana Gradinaru include Laboratory of Molecular Biology & Howard Hughes Medical Institute.
Papers
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Structure-Guided Rational Design of Adeno-Associated Viral Capsids with Expanded Sizes
Xiaozhe Ding,Viviana Gradinaru +1 more
TL;DR: Two rational design strategies that lead to eXtra Large AAV capsids (XL-AAVs) are presented, which represent the first steps towards creating rAAV vectors with larger clone capacities, opening a path towards the delivery of disease-related genes and genetically-encoded tools with long coding sequences in single rAAVs.
Patent
Method for optically controlling a neuron with a mammalian codon optimized nucleotide sequence that encodes a variant opsin polypeptide derived from natromonas pharaonis (NpHR)
TL;DR: In this paper, a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light activated Nphr-based molecules and a promoter is described.
Posted ContentDOI
RecV recombinase system for spatiotemporally controlled light-inducible genomic modifications.
Ali Cetin,Shenqin Yao,Ben Ouellette,Pooja Balaram,Thomas Zhou,Marty Mortrud,Soumya Chatterjee,Yun Wang,Tanya L. Daigle,Bosiljka Tasic,Xiuli Kuang,Hui Gong,Qingming Luo,Shaoqun Zeng,Anat Kahan,Viviana Gradinaru,Hongkui Zeng +16 more
TL;DR: It is shown that light-inducible recombinases can produce highly targeted, sparse and strong labeling of individual neurons thereby enabling whole-brain morphological reconstruction to identify their axonal projection specificity.
Journal ArticleDOI
Lee et al. reply
Jin Hyung Lee,Jin Hyung Lee,Remy Durand,Viviana Gradinaru,Feng Zhang,Inbal Goshen,Dae-Shik Kim,Dae-Shik Kim,Lief E. Fenno,Charu Ramakrishnan,Karl Deisseroth +10 more
TL;DR: In this paper, Logothetis et al. discuss the contribution from additional cells and processes downstream of the defined optically triggered population, including many other circuit and feedback mechanisms and classes of cells within neural circuitry.