L
Lin Tian
Researcher at University of California, Davis
Publications - 180
Citations - 12981
Lin Tian is an academic researcher from University of California, Davis. The author has contributed to research in topics: Cellular network & Throughput. The author has an hindex of 39, co-authored 167 publications receiving 10335 citations. Previous affiliations of Lin Tian include Janelia Farm Research Campus & City University of Hong Kong.
Papers
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Journal ArticleDOI
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Lin Tian,S. Andrew Hires,Tianyi Mao,Daniel Huber,M. Eugenia Chiappe,Sreekanth H. Chalasani,Leopoldo Petreanu,Jasper Akerboom,Sean A McKinney,Sean A McKinney,Eric R. Schreiter,Cornelia I. Bargmann,Vivek Jayaraman,Karel Svoboda,Loren L. Looger +14 more
TL;DR: A single-wavelength GCaMP2-based GECI (GCaMP3) is developed, with increased baseline fluorescence, increased dynamic range and higher affinity for calcium, and long-term imaging in the motor cortex of behaving mice revealed large fluorescence changes in imaged neurons over months.
Journal ArticleDOI
Optimization of a GCaMP calcium indicator for neural activity imaging.
Jasper Akerboom,Tsai Wen Chen,Trevor J. Wardill,Lin Tian,Lin Tian,Jonathan S. Marvin,Sevinç Mutlu,Sevinç Mutlu,Nicole Carreras Calderón,Nicole Carreras Calderón,Nicole Carreras Calderón,Federico Esposti,Bart G. Borghuis,Bart G. Borghuis,Xiaonan Richard Sun,Andrew Gordus,Michael B. Orger,Michael B. Orger,Ruben Portugues,Florian Engert,John J. Macklin,Alessandro Filosa,Aman Aggarwal,Aman Aggarwal,Rex Kerr,Ryousuke Takagi,Sebastian Kracun,Eiji Shigetomi,Baljit S. Khakh,Herwig Baier,Leon Lagnado,Samuel S.-H. Wang,Cornelia I. Bargmann,Bruce E. Kimmel,Vivek Jayaraman,Karel Svoboda,Douglas S. Kim,Eric R. Schreiter,Eric R. Schreiter,Loren L. Looger +39 more
TL;DR: GCaMP5 fluorescence provides a more reliable measure of neuronal activity than its predecessor GCaMP3, which allows more sensitive detection of neural activity in vivo and may find widespread applications for cellular imaging in general.
Journal ArticleDOI
An optimized fluorescent probe for visualizing glutamate neurotransmission
Jonathan S. Marvin,Bart G. Borghuis,Bart G. Borghuis,Lin Tian,Lin Tian,Joseph Cichon,Mark T. Harnett,Jasper Akerboom,Andrew Gordus,Sabine L. Renninger,Tsai Wen Chen,Cornelia I. Bargmann,Michael B. Orger,Eric R. Schreiter,Jonathan B. Demb,Wen-Biao Gan,S. Andrew Hires,Loren L. Looger +17 more
TL;DR: An intensity-based glutamate-sensing fluorescent reporter with signal-to-noise ratio and kinetics appropriate for in vivo imaging is described and its utility for visualizing glutamate release by neurons and astrocytes in increasingly intact neurological systems is validated.
Journal ArticleDOI
Functional imaging of hippocampal place cells at cellular resolution during virtual navigation
TL;DR: Methods for imaging the activity of neurons in the CA1 region of the hippocampus with subcellular resolution in behaving mice with the combination of virtual reality and high-resolution functional imaging are described.
Journal ArticleDOI
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
Tommaso Patriarchi,Jounhong Ryan Cho,Katharina Merten,Mark W. Howe,Aaron Marley,Wei Hong Xiong,Robert W. Folk,Gerard Joey Broussard,Ruqiang Liang,Min Jee Jang,Haining Zhong,Daniel A. Dombeck,Mark von Zastrow,Axel Nimmerjahn,Viviana Gradinaru,John T. Williams,Lin Tian +16 more
TL;DR: The development and validation of dLight1 is reported, a novel suite of intensity-based genetically encoded dopamine indicators that enables ultrafast optical recording of neuronal dopamine dynamics in behaving mice and permits robust detection of physiologically and behaviorally relevant dopamine transients.