V
Viviana Gradinaru
Researcher at California Institute of Technology
Publications - 160
Citations - 21884
Viviana Gradinaru is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 49, co-authored 137 publications receiving 16560 citations. Previous affiliations of Viviana Gradinaru include Laboratory of Molecular Biology & Howard Hughes Medical Institute.
Papers
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Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling
Lucas T. Graybuck,Tanya L. Daigle,Adriana E. Sedeno-Cortes,Miranda Walker,Brian E. Kalmbach,Garreck H. Lenz,Thuc Nghi Nguyen,Emma Garren,Tae Kyung Kim,La'Akea Sieverts,Jacqueline L. Bendrick,Thomas Zhou,Marty Mortrud,Shenqin Yao,Ali Cetin,Rachael Larsen,Luke Esposito,Bryan B. Gore,Eric R. Szelenyi,Elyse Morin,John K. Mich,Nick Dee,Jeff Goldy,Kimberly A. Smith,Zizhen Yao,Viviana Gradinaru,Susan M. Sunkin,Ed S. Lein,Boaz P. Levi,Jonathan T. Ting,Hongkui Zeng,Bosiljka Tasic +31 more
TL;DR: This approach combines unprecedented flexibility with specificity for investigation of cell types in the mouse brain and beyond.
Journal ArticleDOI
RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations.
Shenqin Yao,Peng Yuan,Ben Ouellette,Thomas Zhou,Marty Mortrud,Pooja Balaram,Soumya Chatterjee,Yun Wang,Tanya L. Daigle,Bosiljka Tasic,Xiuli Kuang,Hui Gong,Qingming Luo,Shaoqun Zeng,Andrew Curtright,Ajay Dhaka,Anat Kahan,Viviana Gradinaru,Radosław Chrapkiewicz,Mark J. Schnitzer,Hongkui Zeng,Ali Cetin,Ali Cetin,Ali Cetin +23 more
TL;DR: RecVs enable spatiotemporally precise optogenomic modifications that can facilitate detailed single-cell analysis of neural circuits by linking genetic identity, morphology, connectivity and function.
Journal ArticleDOI
TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice
Jianxiong Zeng,Yaoming Wang,Zhifei Luo,Lin-Chun Chang,Ji-Seung Yoo,Huan Yan,Younho Choi,Xiaochun Xie,Benjamin E. Deverman,Viviana Gradinaru,Stephanie L. Gupton,Berislav V. Zlokovic,Zhen Zhao,Jae U. Jung +13 more
TL;DR: It is revealed that TRIM9 is essential for resolving NF-κB-dependent neuroinflammation to promote recovery and repair after brain injury and may represent an attractive therapeutic target.
Patent
Methods for phenotyping of intact whole tissues
Viviana Gradinaru,Bin Yang +1 more
TL;DR: In this article, the authors present methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity.
Journal ArticleDOI
Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1
J. Elliott Robinson,Gerard M. Coughlin,Acacia Hori,Jounhong Ryan Cho,Elisha D.W. Mackey,Zeynep Turan,Tommaso Patriarchi,Lin Tian,Viviana Gradinaru +8 more
TL;DR: It is found that NF1 mice exhibit reduced spontaneous dopaminergic neurotransmission that was associated with excitation/inhibition imbalance in the ventral tegmental area and abnormal neuronal morphology.