V
Volker Briken
Researcher at University of Maryland, College Park
Publications - 70
Citations - 4675
Volker Briken is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Mycobacterium tuberculosis & Antigen processing. The author has an hindex of 34, co-authored 64 publications receiving 4129 citations. Previous affiliations of Volker Briken include Albert Einstein College of Medicine & University of Freiburg.
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Journal ArticleDOI
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
TL;DR: It is hypothesized that the LAM/LM ratio might be a crucial factor in determining the virulence of a mycobacterial species and the outcome of the infection.
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Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals
Da Ma,Gaya Hettiarachchi,Duc Nguyen,Ben Zhang,James B. Wittenberg,Peter Y. Zavalij,Volker Briken,Lyle Isaacs +7 more
TL;DR: A new class of general-purpose solubilizing agents—acyclic cucurbituril-type containers—which increase the solubility of ten insoluble drugs by a factor of between 23 and 2,750 by forming container–drug complexes are described.
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Mycobacterium tuberculosis nuoG Is a Virulence Gene That Inhibits Apoptosis of Infected Host Cells
Kamalakannan Velmurugan,Bing Chen,Jessica L. Miller,Sharon Azogue,Serdar Abidin Gurses,Tsungda Hsu,Michael S. Glickman,William R. Jacobs,Steven A. Porcelli,Volker Briken +9 more
TL;DR: A key component of the genetic basis for an important virulence trait of M. tuberculosis is identified and a direct causal relationship between virulence of pathogenic mycobacteria and their ability to inhibit macrophage apoptosis is supported.
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Toxicology and Drug Delivery by Cucurbit[n]uril Type Molecular Containers
TL;DR: Very low toxicity of five members of the cucurbit[n]uril family of nanocontainers is revealed, demonstrating the uptake of containers by cells and intracellular release of container-loaded drugs.
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Mycobacterium tuberculosis Lipomannan Induces Apoptosis and Interleukin-12 Production in Macrophages
D. N. Dao,Laurent Kremer,Yann Guérardel,A. Molano,William R. Jacobs,Steven A. Porcelli,Volker Briken +6 more
TL;DR: The ratio of LAM to LM in the cell wall of mycobacteria may be an important determinant of virulence, and enzymes that modify LM could provide targets for development of antituberculosis drugs and for derivation of attenuated strains of M. tuberculosis.