V
Vytas K. Švedas
Researcher at Moscow State University
Publications - 151
Citations - 2737
Vytas K. Švedas is an academic researcher from Moscow State University. The author has contributed to research in topics: Active site & Catalysis. The author has an hindex of 28, co-authored 144 publications receiving 2464 citations. Previous affiliations of Vytas K. Švedas include Laboratory of Molecular Biology & Delft University of Technology.
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Journal ArticleDOI
Guidelines for reporting of biocatalytic reactions
Lucia Gardossi,Poul Børge Rosenius Poulsen,Antonio Ballesteros,Karl Hult,Vytas K. Švedas,Đurđa Vasić-Rački,Giacomo Carrea,Anders Magnusson,Andreas Schmid,Roland Wohlgemuth,Peter J. Halling +10 more
TL;DR: Practical guidelines for reporting experiments on issues such as the selectivity, specificity, productivity and stability of biocatalysts, as well as on methodological problems related to reactions in multiphase systems are given.
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Biocatalytic approach to enantiomerically pure β-amino acids
Vadim A. Soloshonok,Nataly A. Fokina,A. V. Rybakova,I.P. Shishkina,S. V. Galushko,Alexander E. Sorochinsky,Valery P. Kukhar,Mariya V. Savchenko,Vytas K. Švedas +8 more
TL;DR: β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives by using very simple set of reacting chemicals and enzyme.
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Substrate specificity of penicillin amidase from E. coli
TL;DR: Despite the favourable thermodynamic conditions for the production of all beta-lactam antibiotics, low reaction rate is the basic hindrance for enzymatic synthesis of penicillins and cephalosporins having a free amino group in the acyl moiety.
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Biomimetic Transamination of α-Alkyl β-Keto Carboxylic Esters. Chemoenzymatic Approach to the Stereochemically Defined α-Alkyl β-Fluoroalkyl β-Amino Acids
TL;DR: Biomimetic transamination of the commercially available ethyl 2-methyl-3-keto-4, 4,4,4-trifluorobutyrate (4) with benzylamine was shown to provide a simple access to the 2 methyl 3-amino-4.4,
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Biocatalytic resolution of β-fluoroalkyl-β-amino acids
Vadim A. Soloshonok,A. G. Kirilenko,Nataly A. Fokina,I.P. Shishkina,S. V. Galushko,Valery P. Kukhar,Vytas K. Švedas,Elena Kozlova +7 more
TL;DR: In this article, N -Phenylacetyl derivatives of β-fluoroalkyl-β-alanines were synthesized and biocatalytically resolved to the corresponding enantiopure β-amino acids 7,9 with the aid of penicillin acylase (EC 3.5.1.11) from Escherichia coli.