W
W. Andrew Yeudall
Researcher at Georgia Regents University
Publications - 54
Citations - 2167
W. Andrew Yeudall is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cell migration. The author has an hindex of 26, co-authored 52 publications receiving 1929 citations. Previous affiliations of W. Andrew Yeudall include King's College London & Virginia Commonwealth University.
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Journal ArticleDOI
Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.
Alfredo A. Molinolo,Stephen M. Hewitt,Panomwat Amornphimoltham,Somboon Keelawat,Samraeung Rangdaeng,Abelardo Meneses García,Ana R. Raimondi,Rafael Jufe,Maria E. Itoiz,Yan Gao,Dhananjaya Saranath,George S. Kaleebi,George H. Yoo,Lee V. Leak,Ernest M. Myers,Satoru Shintani,David T.W. Wong,H. Davis Massey,W. Andrew Yeudall,Fulvio Lonardo,John F. Ensley,J. Silvio Gutkind +21 more
TL;DR: It is indicated that the Akt-mammalian target of rapamycin (mTOR) pathway is frequently activated in HNSCC, but independently from the activation of epidermal growth factor receptor or the detection of mutant p53.
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Chemokine Function in Periodontal Disease and Oral Cavity Cancer
TL;DR: The biological and biochemical mechanisms of chemokine action in host–microbiome interactions in periodontal disease and in oral cancer are outlined, and how these may overlap and contribute to pathogenesis are outlined.
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Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration
W. Andrew Yeudall,Catherine A. Vaughan,Hiroshi Miyazaki,Mahesh Ramamoorthy,Mi-Yon Choi,Christopher G. Chapman,Huixin Wang,Elena Black,Anna Bulysheva,Swati Palit Deb,Brad Windle,Sumitra Deb +11 more
TL;DR: The data suggest a mechanistic link between GOF p53 proteins and chemokines in enhanced cell motility and short hairpin RNA knockdown of mutant p53 in MDA-MB-231 cells reduced expression of a number of key targets, including several Chemokines and other inflammatory mediators.
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Down-regulation of CXCL5 inhibits squamous carcinogenesis
Hiroshi Miyazaki,Vyomesh Patel,Huixin Wang,Ryan K. Edmunds,J. Silvio Gutkind,W. Andrew Yeudall +5 more
TL;DR: It is suggested that CXCL5 production contributes to both enhanced proliferation and invasion of squamous cell carcinomas and that targeting of chemokine pathways may represent a potential therapeutic modality for these lesions.
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Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility
Rachel J. Paccione,Hiroshi Miyazaki,Vyomesh Patel,Ahmad Waseem,J. Silvio Gutkind,Zendra E. Zehner,W. Andrew Yeudall,W. Andrew Yeudall +7 more
TL;DR: The data suggest that reversal of the mesenchymal phenotype by inhibiting vimentin expression results in reexpression of epithelial characteristics and reduced tumor aggressiveness.