P
Panomwat Amornphimoltham
Researcher at National Institutes of Health
Publications - 46
Citations - 4046
Panomwat Amornphimoltham is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 31, co-authored 43 publications receiving 3705 citations.
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Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal Article
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system
Virote Sriuranpong,Jong-In Park,Panomwat Amornphimoltham,Vyomesh Patel,Barry D. Nelkin,J. Silvio Gutkind +5 more
TL;DR: Constutive activation of STAT3 in HNSCC may use an autocrine/paracrine-activating loop mediated by IL6 and other cytokines acting through the gp130 receptor family, which may confer both proliferative and survival potential in this malignancy.
Journal ArticleDOI
M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway
Daniel H. Madsen,Daniel Leonard,Andrius Masedunskas,Amanda Moyer,Henrik J. Jürgensen,Diane E. Peters,Panomwat Amornphimoltham,Arul Selvaraj,Susan S. Yamada,David A. Brenner,Sven Burgdorf,Lars H. Engelholm,Niels Behrendt,Kenn Holmbeck,Roberto Weigert,Thomas H. Bugge +15 more
TL;DR: Mannose receptor–mediated uptake of collagen by M2-like macrophages is a major mechanism of collagen turnover in mice and it is shown that this mechanism is important for the turnover of collagen in response to injury.
Journal ArticleDOI
Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
Panomwat Amornphimoltham,Vyomesh Patel,Akrit Sodhi,Nikolaos G. Nikitakis,John J. Sauk,Edward A. Sausville,Alfredo A. Molinolo,J. Silvio Gutkind +7 more
TL;DR: The Akt-mTOR pathway is identified as a potential therapeutic target for HNSCC, and may provide the rationale for the early clinical evaluation of rapamycin and its analogues in patients with HNS CC.
Journal ArticleDOI
An essential role for Rac1 in endothelial cell function and vascular development
TL;DR: Findings provide direct evidence that the activity of Rac1 in endothelial cells is essential for vascular development and suggest that Rac1 and its downstream targets may represent promising therapeutic targets for the treatment of numerous human diseases that involve aberrant neovascularization.